PMID: 8940751Sep 1, 1996Paper

Pilot study in locally advanced unresectable pancreas carcinoma using a combination of accelerated radiotherapy and continuous infusion of 5-fluorouracil

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
E C LuderhoffP Bakker

Abstract

Thirteen patients with localized unresectable pancreas carcinoma were treated with a combination of accelerated radiotherapy and 5-fluorouracil. Radiotherapy consisted in 3 fractions of 1.1 Gy per day during 3 weeks up to a total dose of 45-50 Gy. 5-Fluorouracil was administered as continuous infusion in a dosis of 25 mg/kg/24 h the first and the third week concomitantly to radiotherapy. Grade 3 mucositis, diarrhoea and nausea/vomiting were observed in 15% of the patients. Eleven patients completed the treatment without modifications and in two patients the dose of 5-fluorouracil was reduced to 75% during the third week of treatment. Radiotherapy was always administered as planned. Median survival was 36 weeks.

References

Jun 25, 1992·The New England Journal of Medicine·D S Zimmon, R Ferstenberg
Oct 1, 1990·The British Journal of Surgery·G Haddock, D C Carter
Nov 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A L Schuster-UitterhoeveL E Blank
Jun 1, 1983·American Journal of Surgery·K W WarrenS Basu
Nov 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J E ByfieldF Kulhanian

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Citations

Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·E BajettaR Buzzoni
Jul 9, 2002·European Journal of Cancer Care·V E KoulouliasL J Vlahos
May 16, 2000·Cancer Investigation·D J Klaassen
Dec 5, 2003·Alimentary Pharmacology & Therapeutics·S ShoreJ P Neoptolemos
Nov 16, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marjolein J M MorakGeertjan van Tienhoven
Dec 12, 2007·Best Practice & Research. Clinical Gastroenterology·Michel DucreuxDavid Malka
Jul 21, 2006·Japanese Journal of Clinical Oncology·Masanori TsujieMorito Monden

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