Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Tamara IsakovaMyles Wolf

Abstract

High levels of fibroblast growth factor 23 (FGF23) are associated with mortality and progression of chronic kidney disease (CKD). Reducing dietary phosphorus intake lowers FGF23 secretion in healthly individuals, but there is little data on its effects in patients with pre-dialysis CKD. Using a 2×2 factorial design, we randomly assigned 16 normophosphataemic CKD stage 3-4 patients to receive a 2-week treatment with either lanthanum carbonate 1000 mg three times daily or placebo, and to ingest a tightly controlled diet containing 750 or 1500 mg of dietary phosphorus daily. We analysed serial measurements of FGF23, parathyroid hormone, serum phosphate and calcium, and 24-h urinary phosphate and calcium excretion using repeated-measures analyses. Compared with the 1500-mg phosphorus diet, patients assigned to the 750-mg diet had greater reduction in 24-h urinary phosphate excretion (66% vs. 29%; P<0.0001). Lanthanum-treated patients experienced a significant reduction in 24-h urinary phosphate excretion compared with baseline (64%; P<0.0001), but the difference compared with placebo did not reach significance (64% vs. 31%). Despite the significant reductions in 24-h urinary phosphate excretion, no group demonstrated a significant ...Continue Reading

Associated Clinical Trials

References

Apr 1, 1996·The Journal of Nutrition·M S Calvo, Y K Park
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Takashi ShimadaTakeyoshi Yamashita
Jul 21, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Takashi ShigematsuMasafumi Fukagawa
Dec 23, 2004·The Journal of Clinical Endocrinology and Metabolism·Serge L FerrariRené Rizzoli
May 27, 2005·Journal of the American Society of Nephrology : JASN·Orlando GutierrezMyles Wolf
Aug 4, 2005·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Fumihiko KoiwaUNKNOWN ROD21 Clinical Research Group
Nov 2, 2005·Journal of Bone and Mineral Metabolism·Nobuaki ItoToshiro Fujita
Mar 23, 2006·The Journal of Clinical Endocrinology and Metabolism·Erik A ImelMichael J Econs
Jun 1, 2006·The Journal of Clinical Endocrinology and Metabolism·Diana M AntoniucciAnthony A Portale
Jul 28, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sherri -Ann M BurnettJoel S Finkelstein
Aug 31, 2006·Kidney International·I BhanM Wolf
Jan 9, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lourdes CraverElvira Fernández
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Jul 28, 2007·Journal of the American Society of Nephrology : JASN·Danilo FliserPeter Riegler
Nov 10, 2007·The Journal of Clinical Investigation·Iddo Z Ben-DovJustin Silver
Aug 9, 2008·The New England Journal of Medicine·Orlando M GutiérrezMyles Wolf
Dec 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Katherine Wesseling-PerryIsidro B Salusky
Feb 7, 2009·Physiology·Theresa Berndt, Rajiv Kumar
Oct 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Eric N Taylor, Gary C Curhan
Dec 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Rodrigo B OliveiraRosa M A Moysés

❮ Previous
Next ❯

Citations

Mar 11, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jason R Stubbs, Steve Egwuonwu
Nov 7, 2013·Current Osteoporosis Reports·Min Pi, L Darryl Quarles
Mar 26, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Emilio Gonzalez-ParraAlberto Ortiz
Aug 2, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Markus Ketteler, Arndt T Petermann
Aug 4, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maureen A MurtaughSrinivasan Beddhu
Oct 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mhairi SigristAdeera Levin
Aug 27, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rodrigo B de OliveiraRosa M A Moysés
Apr 11, 2012·Current Opinion in Nephrology and Hypertension·Tamara Isakova
Feb 3, 2012·Physiological Reviews·Aline MartinL Darryl Quarles
Jul 24, 2012·Journal of the American Society of Nephrology : JASN·Geoffrey A BlockGlenn M Chertow
May 24, 2014·American Journal of Nephrology·Madhumathi RaoJoachim H Ix
Apr 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Csaba P Kovesdy, Leigh Darryl Quarles
Apr 2, 2014·Nature Reviews. Nephrology·Julia J Scialla, Myles Wolf
May 2, 2014·Seminars in Nephrology·Sophie LiabeufZiad A Massy
Feb 6, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Katherine Wesseling-Perry, Isidro B Salusky
Mar 9, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Tamara IsakovaMyles Wolf
Aug 9, 2011·Journal of Bone and Mineral Metabolism·Seiji Fukumoto, Yuichiro Shimizu
Feb 26, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Cynthia S Ritter, Eduardo Slatopolsky
Jun 11, 2011·International Journal of Nephrology·Markus Ketteler
Feb 26, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Antonio Bellasi
Dec 19, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bryan Kestenbaum
Nov 13, 2013·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Aaltje Y AdemaUNKNOWN NIGRAM Consortium
Jun 15, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Geoffrey A BlockDavid C Wheeler
May 15, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mario CozzolinoGiuseppe Remuzzi
Mar 8, 2013·Seminars in Nephrology·Katherine Wesseling-Perry, Isidro B Salusky
Jul 30, 2015·Kidney International·Maria L MaceEwa Lewin
May 25, 2012·Kidney International·Myles Wolf
Apr 7, 2012·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Julia J SciallaUNKNOWN Chronic Renal Insufficiency Cohort-CRIC Study Group
Mar 13, 2012·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Jessica HoustonOrlando M Gutiérrez
Mar 20, 2012·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Emilio Gonzalez-ParraAlberto Ortiz
Nov 17, 2015·International Urology and Nephrology·Sven-Jean TanNigel D Toussaint
Jul 26, 2011·Journal of Clinical Lipidology·Andrew G BostomWilliam A Hanlon
Apr 19, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Joachim H IxAndrew G Bostom
Mar 17, 2011·Advances in Chronic Kidney Disease·Jessica KendrickMichel Chonchol
Dec 25, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Julie R DominguezUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Research Group
Mar 31, 2012·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Tomasz HryszkoMichal Mysliwiec
Jun 6, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Masafumi FukagawaUNKNOWN Japanese Society for Dialysis Therapy
Aug 30, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nadine M KhouzamIsidro B Salusky
Mar 29, 2014·International Journal of Hypertension·Rika Jimbo, Tatsuo Shimosawa
Apr 28, 2016·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Laura Salanova VillanuevaEsther Ortega Junco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Mandy WanRukshana Shroff
© 2021 Meta ULC. All rights reserved