Pilot study of sex differences in chemokine/cytokine markers of atherosclerosis in humans

Gender Medicine
Joseph LeungVirginia M Miller

Abstract

Atherogenic processes increase in women after menopause, when the risk of cardiovascular adverse events approaches that observed in age-matched men. In experimental animals, ovariectomy increases the platelet content of mitogenic cytokines, such as platelet-derived growth factor (PDGF), which when released into the blood or site of vascular injury, contribute to atherogenic processes. Experiments were designed to assess the sex distribution of inflammatorychemokines/cytokines, which may be released from platelets in the serum of middle-aged women and men in whom the extent of atherosclerotic coronary disease was defined by coronary arterial calcification (CAC). Blood was obtained from healthy white individuals recruited from the Mayo Clinic database. CAC was assessed by 64-slice computed tomography. Plasma cholesterol, lipids, and high-sensitivity C-reactive protein were analyzed by the Mayo Clinic Department of Laboratory Medicine and Pathology. Serum cytokines were determined using cytokine arrays. Cytokine expression was measured using dot blot analysis. Of the 16 individuals (11 women, 5 men) who agreed to participate in the study, 1 woman was premenopausal, 1 was taking oral contraceptives, and 1 was receiving menopausal h...Continue Reading

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Citations

Jan 20, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Helen Hermana M HermsdorffJ Alfredo Martínez
Mar 29, 2012·Journal of Translational Medicine·Janet C SiebertHolden T Maecker
Oct 5, 2010·Women's Health·V M Miller
Dec 19, 2008·The Journal of Clinical Hypertension·Vivencio BarriosAlberto Calderón
Oct 21, 2010·Clinical Science·Amparo C VillablancaCarole Banka

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