Abstract
Olanzapine has demonstrated efficacy in acute mania and bipolar I disorder (BDI) maintenance, but efficacy in brief therapy in more diverse populations, including patients with bipolar II disorder (BDII)/bipolar disorder not otherwise specified (BDNOS) with syndromal/subsyndromal depressive/mood elevation symptoms and taking/not taking concurrent medications remains to be established. Fifty adult outpatients (24 BD1, 22 BDII, 4 BDNOS, mean ± SD age 40.8 ± 11.5 years, 28.1% female, already taking 1.1 ± 1.2 [median 1] prescription psychotropics) with 17-item Hamilton Depression Rating Scale (HDRS) ≥10 and/or Young Mania Rating Scale (YMRS) ≥10 and ≤24, were randomized to double-blind olanzapine (2.5-20 mg/day) versus placebo for one week. Among 45 patients with post-baseline ratings, olanzapine (9.0 ± 5.8 mg/day, n = 23) compared to placebo (n = 22) tended to yield greater Clinical Global Impressions-Bipolar Version-Overall Severity of Illness (-1.4 ± 0.9 versus -0.8 ± 1.1, p = 0.08) and Hamilton Anxiety Scale (-7.9 ± 6.3 versus -3.8 ± 6.1, p = 0.07) improvements, and YMRS/HDRS remission rate (47.8% versus 22.7%, p = 0.08), but significantly increased median weight (+2 versus -1 lbs, p = 0.001), and rates of excessive appetite (5...Continue Reading
References
Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Mar 3, 1998·Psychiatry Research·M K SpearingW Nolen
Sep 15, 2000·Archives of General Psychiatry·M TohenA Breier
Jan 12, 2002·Archives of General Psychiatry·Mauricio TohenAlan Breier
Dec 14, 2002·Bipolar Disorders·Suttiporn JanenawasinTerence A Ketter
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Nov 12, 2003·Archives of General Psychiatry·Mauricio TohenAlan Breier
Nov 13, 2004·Journal of Clinical Psychopharmacology·Jeffrey A WelgeJane M Meinhold
Feb 2, 2006·The American Journal of Psychiatry·Mauricio TohenCharles L Bowden
May 17, 2006·Journal of Clinical Psychopharmacology·Ilya LipkovichThomas Hardy
Jul 31, 2008·BMC Psychiatry·Ilya A LipkovichJonna Ahl
Feb 13, 2009·The Journal of Clinical Psychiatry·Joseph F GoldbergMichael E Thase
Jan 8, 2010·BMC Medical Research Methodology·Lehana ThabaneCharles H Goldsmith
Mar 12, 2010·Child and Adolescent Psychiatry and Mental Health·Erik Parens, Josephine Johnston
Nov 3, 2010·Journal of Psychiatric Research·Andrew C LeonHelena C Kraemer
Dec 8, 2010·Acta Psychiatrica Scandinavica·T A KetterS Srivastava
Jun 11, 2011·Comprehensive Psychiatry·Ana González-IsasiAna González-Pinto