Pilot study of the optimum hematocrit for patients in the predialysis stage after renal transplantation

Transplantation Proceedings
T KawaguchiH Yamanaka

Abstract

Anemia is a common complication in patients with chronic kidney diseases including posttransplant patients. Guidelines for the treatment of anemia in chronic kidney disease published by NHF-K/DOQI recommend the target hemoglobin and hematocrit (Hb and Ht) levels to be in the 11 to 12 g/dL and 33% to 36% ranges, respectively, which are somewhat higher than those recommended in Japan (Ht = 30%). However, these guidelines were established mainly from the data on hemodialysis patients with only limited information available as to the impact of anemia control in posttransplant patients. The aim of the present study was to evaluate cardiac function and quality of life (QOL) when the Ht was raised to about 36% by administration of recombinant-human-erythropoietin (rHuEPO) to patients with mild impairment of renal function (s-Cre < 2.0 mg/dL) after renal transplantation. Twenty-five patients were analyzed for cardiac function, blood data, and QOL in a prospective study encompassing 8 months of rHuEPO treatment. Using a once weekly subcutaneous dose of 6000 IU of Epoetin-beta, the Ht became 33% to 36% and Hb was 11 to 12 g/dL. Among the cardiac function tests, left ventricular end-diastolic diameter and left ventricular mass index decre...Continue Reading

References

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Citations

Aug 6, 2011·Clinical and Experimental Nephrology·Masayoshi OkumiShiro Takahara
May 1, 2010·Transplantation Proceedings·M M Abou-JaoudeW Y Almawi
Aug 2, 2008·Néphrologie & thérapeutique·Gabriel ChoukrounFranck Martinez
Sep 26, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Behdad AfzaliDavid Goldsmith
Jan 10, 2006·Seminars in Dialysis·Elizabeth A Kendrick, Connie L Davis
Dec 1, 2010·Pharmacotherapy·Kristine S SchonderWhitney Yu-Hui Hung
Sep 24, 2015·Surgical Neurology International·Sebastian M ChristEkkehard M Kasper
Mar 4, 2014·Internal Medicine·Hiroshi ItoNobuyuki Marui

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