PMID: 9444649Jan 28, 1998Paper

Pilot study of UFT combined with 5 consecutive days cisplatin in non-small cell lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
S KoinumaruY Nakai

Abstract

Combined use of 5-fluorouracil (5-FU) and cisplatin has proven to have synergistic effects in many experimental systems and clinical studies. UFT, an oral preparation of uracil and tegafur in a 4:1 molar ratio, was reported to have enhanced activity as compared with 5-FU or tegafur alone against various human tumors. Based on those results, we conducted a pilot study to confirm the feasibility and antitumor effect of UFT in combination with cisplatin in patients with advanced non-small cell lung cancer (NSCLC). UFT was orally administered at a dose of 400 mg/m2 according to a protocol for step-wise prolongation of the administration period, such as days 1-14 in step I, days 1-21 in step II, days 1-28 in step III. During to course, cisplatin was administered at a fixed dose of 20 mg/m2/day on days 8 through 12. The course was repeated every 4 weeks. Numbers of patients enrolled in steps I, II, III were six, ten and six (a total of 22), respectively. There were three females and 19 males, PS scored 0/1/2 = 7/14/1, stage IIIA/IIIB/IV = 3/8/11. Adenocarcinoma/squamous cell carcinoma/large cell carcinoma = 11/7/4, and median age 68 (range 52-79). All 22 patients were evaluable for toxicity, and 21 for efficacy. Compliance of UFT dec...Continue Reading

References

Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K J ScanlonD G Priest
Jan 1, 1985·Cancer Chemotherapy and Pharmacology·Y MatsushimaN Saijo
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Jul 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R C Lilenbaum, M R Green

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Citations

Dec 21, 2000·Current Oncology Reports·C J Langer
Nov 21, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M HigashiyamaH Kobayashi
Oct 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·C J Langer
Feb 13, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J SaitoT Nakabayashi
Jun 16, 2001·Current Problems in Cancer·C H Takimoto

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