Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age

Pediatric Obesity
F MarzanoA Tullo

Abstract

Children born small for gestational age (SGA) are at increased risk of metabolic dysfunction. Dysregulation of specific microRNAs (miRNAs) contributes to aberrant gene expression patterns underlying metabolic dysfunction. We aimed to determine and compare circulating miRNA (c-miRNA) profile of SGA and appropriate for gestational age (AGA) children with obesity and with normal weight, in order to identify biomarkers for early detection of increased risk of developing metabolic dysfunction in SGA and AGA children with obesity. Small non-coding RNAs from serum of 15 SGA children with obesity (OB-SGA), 10 SGA children with normal weight (NW-SGA), 17 AGA children with obesity (OB-AGA) and 12 AGA children with normal weight (NW-AGA) (mean age 11.2 ± 2.6) have been extracted and sequenced in order to detect and quantify miRNA expression profiles. RNA-seq analyses showed 28 miRNAs dysregulated in OB-SGA vs. NW-SGA and 19 miRNAs dysregulated in OB-AGA vs. NW-AGA. Among these, miR-92a-3p, miR-122-5p, miR-423-5p, miR-484, miR-486-3p and miR-532-5p were up regulated, and miR-181b-5p was down regulated in both OB-SGA and OB-AGA compared with normal weight counterparts. Pathway analysis and miRNA target prediction suggested that these miRNAs...Continue Reading

References

Oct 26, 1991·BMJ : British Medical Journal·C N HalesP D Winter
Jun 22, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·S CianfaraniF Branca
Mar 9, 2005·Lancet·Joy E LawnUNKNOWN Lancet Neonatal Survival Steering Team
Dec 24, 2005·RNA·Praveen SethupathyArtemis G Hatzigeorgiou
Mar 16, 2006·The Journal of Clinical Endocrinology and Metabolism·Lourdes IbáñezFrancis de Zegher
May 25, 2006·Clinical Obstetrics and Gynecology·David J P Barker
Aug 7, 2009·Human Molecular Genetics·Elmar W TobiBastiaan T Heijmans
Dec 17, 2009·The Journal of Pediatrics·Lourdes IbáñezFrancis de Zegher
Jan 5, 2010·Metabolism: Clinical and Experimental·Xinhua XiaoZeng Yi
Aug 2, 2012·Experimental Diabetes Research·Michael D Williams, Geraldine M Mitchell
Aug 10, 2013·The Journal of Clinical Endocrinology and Metabolism·Anna Prats-PuigJosé M Fernández-Real
Dec 2, 2014·Obesity Research & Clinical Practice·Ramona StroescuGabriela Doroş
Dec 18, 2014·European Journal of Endocrinology·Rui WangWeiqing Wang
Nov 22, 2015·Nucleic Acids Research·Chih-Hung ChouHsien-Da Huang
Dec 20, 2015·Journal of Cellular Biochemistry·David E LeeNicholas P Greene
Jan 20, 2016·Pediatric Obesity·M L MansegoUNKNOWN GENOI members
May 11, 2016·Hormone Research in Pædiatrics·Pamela Fischer-PosovszkyMartin Wabitsch
Nov 4, 2016·Nature Reviews. Endocrinology·Veronica MericqAnita Hokken-Koelega

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Citations

May 28, 2019·Frontiers in Endocrinology·Maria Felicia FaienzaGiacomina Brunetti
Jun 23, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Gunter Matthias Christian FlemmingWieland Kiess
Feb 23, 2020·Frontiers in Genetics·Annalisa DeodatiStefano Cianfarani
Feb 6, 2020·World Journal of Pediatrics : WJP·Maria Felicia FaienzaPiero Portincasa
Nov 21, 2021·Pediatric Research·Cristina Garcia-BeltranLourdes Ibáñez

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