Pilot Study on Dose-Dependent Effects of Transcranial Photobiomodulation on Brain Electrical Oscillations: A Potential Therapeutic Target in Alzheimer's Disease.

Journal of Alzheimer's Disease : JAD
Vincenza SperaPaolo Cassano

Abstract

Transcranial photobiomodulation (tPBM) has recently emerged as a potential cognitive enhancement technique and clinical treatment for various neuropsychiatric and neurodegenerative disorders by delivering invisible near-infrared light to the scalp and increasing energy metabolism in the brain. We assessed whether transcranial photobiomodulation with near-infrared light modulates cerebral electrical activity through electroencephalogram (EEG) and cerebral blood flow (CBF). We conducted a single-blind, sham-controlled pilot study to test the effect of continuous (c-tPBM), pulse (p-tPBM), and sham (s-tPBM) transcranial photobiomodulation on EEG oscillations and CBF using diffuse correlation spectroscopy (DCS) in a sample of ten healthy subjects [6F/4 M; mean age 28.6±12.9 years]. c-tPBM near-infrared radiation (NIR) (830 nm; 54.8 mW/cm2; 65.8 J/cm2; 2.3 kJ) and p-tPBM (830 nm; 10 Hz; 54.8 mW/cm2; 33%; 21.7 J/cm2; 0.8 kJ) were delivered concurrently to the frontal areas by four LED clusters. EEG and DCS recordings were performed weekly before, during, and after each tPBM session. c-tPBM significantly boosted gamma (t = 3.02, df = 7, p < 0.02) and beta (t = 2.91, df = 7, p < 0.03) EEG spectral powers in eyes-open recordings and gamm...Continue Reading

References

Mar 19, 1999·Brain and Language·E BaşarA Ademoglu
May 14, 1999·Trends in Cognitive Sciences·C Tallon-Baudry, O Bertrand
Nov 6, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Daniel Senkowski, Christoph S Herrmann
Jul 17, 2004·Neuroreport·Thomas GruberMatthias M Müller
Jul 21, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Niko A BuschChristoph S Herrmann
Nov 24, 2004·The Journal of Biological Chemistry·Margaret T T Wong-RileyHarry T Whelan
Oct 29, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·C S Herrmann, T Demiralp
Jul 5, 2006·The European Journal of Neuroscience·Attila I GulyásHajime Hirase
Jul 13, 2006·Cerebral Cortex·Per B SederbergMichael J Kahana
Jul 21, 2006·Neurobiology of Aging·K van der HieleH A M Middelkoop
Apr 26, 2007·PLoS Biology·Joachim GrossMarkus Ploner
Dec 21, 2007·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Balázs CziglerMárk Molnár
Feb 11, 2009·American Journal of Alzheimer's Disease and Other Dementias·D V MorettiG B Frisoni
Mar 18, 2009·Lasers in Surgery and Medicine·Philip BrondonRaymond J Lanzafame
Sep 12, 2009·Neuroscience and Biobehavioral Reviews·Christoph S HerrmannDaniel Lenz
Jul 28, 2010·Lasers in Surgery and Medicine·Yoichi UozumiMakoto Kikuchi
Jun 15, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Cristina Rosazza, Ludovico Minati
Oct 1, 2011·Lasers in Surgery and Medicine·Sulbha K SharmaMichael R Hamblin
Mar 27, 2012·Annual Review of Neuroscience·György Buzsáki, Xiao-Jing Wang
Sep 24, 2013·Supplements to Clinical Neurophysiology·Erol BaşarGörsev Gülmen Yener
Apr 9, 2014·Neuropsychologia·Bahar Güntekin, Erol Başar
Oct 4, 2014·Lasers in Medical Science·Afonso S I SalgadoIvo I Kerppers
Dec 30, 2014·Frontiers in Neuroscience·Lukas V GalowOliver Kann
Jan 17, 2015·Neurophotonics·Erin M BuckleyMaria Angela Franceschini
Feb 11, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Christoph S HerrmannAndreas K Engel
Mar 17, 2015·Lasers in Surgery and Medicine·Clark E TedfordJuanita Anders
May 29, 2015·Journal of Neuropsychology·Nathaniel J BlancoFrancisco Gonzalez-Lima
Jan 29, 2016·Lasers in Surgery and Medicine·Fenghua TianHanli Liu
Apr 21, 2016·Current Neurology and Neuroscience Reports·David Roh, Soojin Park
Dec 9, 2016·Nature·Hannah F IaccarinoLi-Huei Tsai
Feb 10, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Xinlong WangHanli Liu
May 4, 2017·Lasers in Medical Science·Enrique VargasF Gonzalez-Lima
Jun 6, 2017·Journal of Optics·Madison Hennessy, Michael R Hamblin
Feb 14, 2018·Neuroscience Research·Tomoaki NakazonoKei M Igarashi

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Citations

Aug 31, 2021·Journal of Alzheimer's Disease : JAD·Michael R Hamblin, Farzad Salehpour

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