PMID: 8581325Jan 1, 1995Paper

Pilot study on the plasma pharmacokinetics of fumonisin B1 in cows following a single dose by oral gavage or intravenous administration

Natural Toxins
D B PreluskyH L Trenholm

Abstract

The pharmacokinetic fate of the mycotoxin fumonisin B1 (FB1) was investigated using 4 Holstein cows. Two animals each were administered FB1 intravenously (0.05 or 0.20 mg kg-1) and by oral gavage (1.0 or 5.0 mg kg-1). Blood samples were collected at specific time intervals over 12 hr postdosing, then daily for 13 more days, and analyzed for FB1, the hydroxylated aminopental metabolite, and their conjugates. Following intravenous dosing, the plasma-concentration profile of FB1 underwent a very rapid biexponential decrease, with toxin concentrations falling below detectable levels by 120 min postdosing. No known metabolites were detected in plasma. The similarity in pharmacokinetic parameters between the low- and high-dose animals suggests that FB1 distribution and elimination from blood was not dose-dependent at these levels of toxin administration. Following oral administration of the toxin, no FB1 or known metabolites could be found in the plasma, indicating no or very limited bioavailability in ruminants. The effects of FB1 on plasma-free sphinganine (Sa) and free sphingosine (So) concentrations were also determined. Following oral gavage at either dose, no effects on plasma sphingolipid concentration or Sa/So ratio were note...Continue Reading

References

Jul 1, 1992·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·D R LedouxG E Rottinghaus
Jul 1, 1990·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·L R HarrisonJ R Cole
Jan 1, 1994·Natural Toxins·D B PreluskyM E Savard
May 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G S ShephardJ F Alberts
Feb 1, 1993·Journal of Animal Science·G D OsweilerT M Wilson
Jun 1, 1994·Journal of Food Protection·Larry G Rice, P Frank Ross
Jun 1, 1994·Journal of Food Protection·Ronald T RileyAlfred H Merrill

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Citations

Aug 8, 2002·Toxicon : Official Journal of the International Society on Toxinology·F CaloniI De Angelis
May 5, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G S Shephard, P W Snijman
Apr 17, 2001·Food Additives and Contaminants·R R Delongchamp, J F Young
Aug 14, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Didier TardieuPhilippe Guerre
Mar 31, 2009·Chemico-biological Interactions·R B OrsiB Corrêa
Oct 2, 2007·Toxicology and Applied Pharmacology·Qingsong CaiJia-Sheng Wang
Jun 3, 1999·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·D C Baker, G E Rottinghaus
Jul 21, 2007·Molecular Nutrition & Food Research·Sandrine Bouhet, Isabelle P Oswald
May 25, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Isabelle P Oswald
Feb 23, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Jan Alexander
Jun 20, 2018·Toxins·Alessia BerteroFrancesca Caloni

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