Abstract
The PI3K/Akt/mTOR signal pathway is involved in hepatocarcinogenesis. Rapamycin (=sirolimus), a specific mTOR inhibitor, leads to G(1) arrest of many malignant cell lines and currently, analogues of rapamycin are being investigated as a cancer chemotherapeutic adjuvant. To study the toxicity and tolerability of rapamycin therapy in patients with advanced hepatocellular carcinoma (HCC). Between June 2005 and February 2007, patients with advanced HCC, not eligible for any established therapy, were included in the study. Eighteen patients (F/M: 5/13) with compensated liver cirrhosis (Child A n = 11, Child B n = 5, Child C n = 2) and histologically proven HCC were included in this study. According to the BCLC staging system, most of the patients enrolled had an advanced HCC: BCLC stage B: n = 2, Barcelona Clinic Liver-Cancer (BCLC) stage C: n = 14, BCLC stage D: n = 2. Overall, therapy with rapamycin was well tolerated. Most common toxicities were thrombocytopaenia and anaemia. We did not observe any partial or complete tumour response. At 3 months, two patients had stable disease and at 6 months, all patients had progressed. The median overall survival was 5.27 months, median time to progression was 3 months. Rapamycin is well tol...Continue Reading
References
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·N TeradaE W Gelfand
Jan 1, 1994·Medicinal Research Reviews·S N SehgalB M Weichman
Jun 1, 1997·The EMBO Journal·H B JefferiesG Thomas
Oct 13, 1999·Seminars in Liver Disease·J M LlovetJ Bruix
Feb 3, 2000·Journal of the National Cancer Institute·P TherasseS G Gwyther
Oct 11, 2001·Journal of Hepatology·J BruixUNKNOWN EASL Panel of Experts on HCC
Feb 8, 2002·Cancer Metastasis Reviews·S Huang, P J Houghton
Jul 2, 2002·Radiology·Calogero CammàMario Cottone
May 7, 2003·Radiology·Robert P Myers
May 14, 2003·Transplantation Proceedings·E Morelon, H Kreis
May 14, 2003·Transplantation Proceedings·B Radovancevic, B Vrtovec
May 14, 2003·Transplantation Proceedings·J F Trotter
Sep 18, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Norman M KnetemanDavid L Bigam
Apr 9, 2005·Transplantation·Mohammed ElsharkawiJens Mayer
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
Nov 16, 2005·Transplantation·Joachim AndrassyMarkus Guba
May 24, 2006·World Journal of Gastroenterology : WJG·Jian ZhouZhao-You Tang
Jun 16, 2007·Gastroenterology·Hashem B El-Serag, K Lenhard Rudolph
May 15, 2008·Journal of the National Cancer Institute·Josep M LlovetUNKNOWN Panel of Experts in HCC-Design Clinical Trials
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Sep 24, 2008·Alimentary Pharmacology & Therapeutics·M ChaparroR Moreno-Otero
Oct 22, 2008·Gastroenterology·Augusto VillanuevaJosep M Llovet
Dec 5, 2008·The New England Journal of Medicine·Giancarlo Spinzi, Silvia Paggi
Aug 12, 2009·Journal of Hepatology·Pippa NewellJosep M Llovet
Nov 17, 2009·Alimentary Pharmacology & Therapeutics·E G GianniniUNKNOWN ITALIAN LIVER CANCER (ITA.LI.CA.) GROUP
Nov 21, 2009·Alimentary Pharmacology & Therapeutics·R Cabrera, D R Nelson
Feb 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christian TosoNorman M Kneteman
Citations
Jun 23, 2012·Digestive Diseases·Anna GiacominFabio Farinati
Oct 14, 2011·Future Oncology·Qian ZhouWinnie Yeo
Apr 25, 2012·Experimental and Molecular Pathology·Jennifer A SandersPhilip A Gruppuso
Mar 16, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Martha M KirsteinArndt Vogel
Nov 9, 2012·Alimentary Pharmacology & Therapeutics·H-S ShiahL-T Chen
Aug 1, 2015·Biochemical and Biophysical Research Communications·Hamed Nayeb-HashemiChinweike Ukomadu
Dec 7, 2013·Journal of Hepatology·Matthias S MatterSnorri S Thorgeirsson
May 20, 2015·Gastroenterology·Xinxin ChenHongbing Zhang
Apr 12, 2013·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Sang Jun Suh, Hyung Joon Yim
Feb 15, 2014·Oncology Letters·Penpak MoolthiyaKawin Leelawat
Nov 16, 2019·European Journal of Pharmacology·Michał AntoszczakAdam Huczyński
Jul 12, 2021·Oncogene·Er-Bin ZhangJing-Jing Li