Pilot study to assess the influence of beta-blockade on mitral regurgitant volume and left ventricular work in degenerative mitral valve disease

Circulation
Ralph A H StewartBrett R Cowan

Abstract

A medical treatment that decreases the likelihood of left ventricular (LV) dysfunction or symptoms would benefit patients with moderate to severe degenerative mitral regurgitation. The aim of this pilot study was to determine the short-term effects of a beta-blocker on mitral regurgitant volume and LV work in these patients. Twenty-five patients with moderate or severe degenerative mitral regurgitation were randomized in a double-blind crossover study to the beta(1)-selective adrenergic blocker metoprolol (mean daily dose, 119 mg; range 23.75 to 190 mg) and placebo for 14+/-3 days. At the end of each treatment period, ascending aortic flow and LV stroke volume were measured by cardiac magnetic resonance imaging, and mitral regurgitant volume was calculated. On beta-blocker, heart rate decreased from 65+/-10 by 10+/-7 bpm (mean+/-SD) and systolic blood pressure decreased from 138+/-18 by 16+/-12 mm Hg (P<0.0001 for both). No significant change occurred in LV ejection fraction (from 65+/-5%; change, -0.6+/-2.7%; P=0.3) or mitral regurgitant volume (from 59+/-36 mL; change, 3+/-13 mL; P=0.3), but forward stroke volume increased from 89+/-21 by 5+/-11 mL (P=0.03). Because heart rate was lower on metoprolol, cardiac output decreased...Continue Reading

References

Aug 26, 1998·Journal of the American College of Cardiology·A M KizilbashP A Grayburn
Dec 10, 1999·Journal of the American College of Cardiology·F GrigioniR L Frye
Jul 2, 2003·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·William A ZoghbiUNKNOWN American Society of Echocardiography
Mar 5, 2005·The New England Journal of Medicine·Maurice Enriquez-SaranoA Jamil Tajik
Jan 31, 2006·Lancet·Lionel H OpieMarc A Pfeffer
Jun 15, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Gerald H HankesLouis J Dell'Italia
Jul 4, 2006·Journal of the American College of Cardiology·Allan S JaffeFred S Apple
Mar 16, 2007·The New England Journal of Medicine·Stefan Neubauer

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Citations

Nov 26, 2009·Current Treatment Options in Cardiovascular Medicine·Blase A Carabello
Sep 18, 2010·Circulation. Cardiovascular Imaging·Daniel B EnnisRalph A H Stewart
Jun 21, 2011·Biomedical Engineering Online·Wee-Beng TayWen-Yih Tseng
Nov 26, 2013·Heart, Lung & Circulation·Yin HongningGillian A Whalley
Jun 13, 2009·Current Opinion in Cardiology·Ralph A H Stewart
Jan 22, 2013·The American Journal of Cardiology·Chun G SchirosLouis J Dell'Italia
Mar 1, 2012·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Sonya G GordonMatthew W Miller
Jan 16, 2014·International Journal of Clinical Practice·R Ray, J Chambers
Jan 8, 2011·The American Journal of Cardiology·Meike RybczynskiYskert von Kodolitsch
Jul 24, 2012·Journal of the American College of Cardiology·Mustafa I AhmedLouis J Dell'Italia
Apr 12, 2013·Heart·John B ChambersUNKNOWN British Heart Valve Society
Jul 19, 2013·Circulation. Heart Failure·Jeffrey S Borer
Mar 2, 2019·Current Hypertension Reports·Vasiliki KatsiDimitrios Tousoulis

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