Pilot study to evaluate the efficacy of lymphotropic nanoparticle enhanced MRI for diagnosis of metastatic disease in canine head and neck tumours.

Veterinary and Comparative Oncology
Lynn GriffinBernard Seguin

Abstract

This pilot study is designed to determine if lymphotropic nanoparticle enhanced MRI (LNMRI) is a viable technique for staging of naturally occurring canine malignant head and neck tumours. Previous imaging studies in veterinary medicine have shown variable sensitivity and specificity for determining metastasis for local lymph nodes in head and neck tumours. LNMRI utilizes ultra-small superparamagnetic iron oxide nanoparticles (USPIOs) to help in the detection of metastatic disease in lymph nodes. USPIOs are phagocytized and localized to normal lymph nodes where they assist in evaluation for regions of effacement by cancerous cells. Six dogs underwent LNMRI for the diagnosis of metastatic lymph nodes. A truncated MRI consisting of transverse images of T2, T1 pre- and post-contrast and T2* sequences were evaluated for presence of metastasis. Sentinel lymph nodes and lymph nodes with possible metastatic lesions were surgically excised for histological evaluation. In the initial phase of this study, 24 lymph nodes were included in analysis. Subjective observation by the primary investigator had a calculated sensitivity and specificity of 100% and 88% based on histological results. There were no negative side effects to the USPIOs n...Continue Reading

References

Nov 1, 1996·The Journal of Veterinary Medical Science·T YamagamiM Sugiyama
Nov 24, 1998·Journal of the American Animal Hospital Association·J CrawshawR A Henderson
Dec 6, 2000·Journal of Magnetic Resonance Imaging : JMRI·H K PannuD A Bluemke
Feb 28, 2002·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Dongwoo ChangJekyung Seong
Jan 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Silke AumannGunnar Brix
May 3, 2003·Journal of the American Veterinary Medical Association·Laurel E Williams, Rebecca A Packer
Apr 23, 2005·Journal of the American Veterinary Medical Association·Kim R HillersSusan E Lana
Feb 14, 2006·European Journal of Radiology·Mansi A SaksenaMukesh G Harisinghani
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Merrick I Ross
May 9, 2006·Abdominal Imaging·A SaokarM Harisinghani
Aug 30, 2007·The Journal of Small Animal Practice·G A PoltonC A Burton
May 8, 2008·CA: a Cancer Journal for Clinicians·Frederick L Greene, Leslie H Sobin
Jun 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Jing LeiZheng Yu Jin
Sep 3, 2010·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Elizabeth A BallegeerNicholas S Keuler
Dec 18, 2010·Journal of the American Animal Hospital Association·Carrie Tupper HumeKarin U Sorenmo
Jun 24, 2015·AJR. American Journal of Roentgenology·Baris TurkbeyPeter L Choyke
Dec 23, 2016·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Christina SoultaniTatiana M Ilia
Nov 13, 2018·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Jessica A StahleDana Neelis

❮ Previous
Next ❯

Citations

Feb 27, 2021·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Sabrina WilsonAllison L Zwingenberger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.