Abstract
Atopic dermatitis (AD) is a major public health concern worldwide. Given its rising prevalence, there is a pressing need to study its epidemiology. To date, no validated, cost-effective, and patient self-administered screening instrument exists that can reliably distinguish AD from other skin conditions. Our aim is to develop an instrument that can validate a self-reported AD diagnosis quickly and with reasonable accuracy in a population at a distance. A one-page, 13-question atopic dermatitis screening and evaluation questionnaire (ADSEQ) was generated after literature review and consultation with dermatologists. The questionnaire was administered to 121 patients with and without AD in a dermatology clinic. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated for all questions. The questions with the highest sensitivities were selected for logistic regression analysis, and a receiver operating characteristics curve was plotted. Four scoring algorithms using different combinations of responses were then developed. A combination of Q7 (itching) and Qpic (the image questions combined) had the highest sensitivity (96.3%) and specificity (84%) for a diagnosis of AD. Cronbach's alpha coe...Continue Reading
References
Dec 1, 1992·Acta Paediatrica·O LinnaO Tammela
Nov 1, 1992·Clinical and Experimental Dermatology·H C Williams
Jul 1, 1983·Allergy·R LuomaM Viander
May 1, 1993·Journal of the American Academy of Dermatology·F Schultz Larsen
Jun 27, 2001·Postgraduate Medicine·S Leicht, M Hanggi
Sep 13, 2001·Contact Dermatitis·B Meding, L Barregård
Jan 18, 2003·Lancet·Donald Y M Leung, Thomas Bieber
Feb 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Edward A BelongiaRobert T Chen
May 12, 2007·The British Journal of Dermatology·M WolkewitzT L Diepgen
Jun 25, 2009·Current Opinion in Allergy and Clinical Immunology·Peter M Elias, Matthias Schmuth
Aug 7, 2009·Current Allergy and Asthma Reports·Peter M Elias, Matthias Schmuth
Dec 17, 2009·The Journal of Allergy and Clinical Immunology·Emma Guttman-YasskyJames G Krueger
Dec 17, 2009·The Journal of Allergy and Clinical Immunology·Joseph A OdhiamboUNKNOWN ISAAC Phase Three Study Group
Nov 11, 2010·BMC Dermatology·Agostino StrinaLaura C Rodrigues
Jul 19, 2012·PloS One·Ivette A G DeckersAziz Sheikh
Jan 12, 2013·Acta Dermato-venereologica·Kerstin BingeforsMagnus Lindberg