Pilot validation of objective malnutrition-inflammation scores in pediatric and adolescent cohort on chronic maintenance dialysis

SAGE Open Medicine
Franca M Iorember, Oluwatoyin F Bamgbola

Abstract

In recognition of the challenges inherent with the use of single-item indices for the diagnosis of malnutrition-inflammation morbidity in pediatric dialysis patients, to enhance accuracy, we validated a composite scoring system in a pilot study. The objective malnutrition-inflammation score seeks to validate the use of a composite scoring system as a tool for assessing malnutrition-inflammation burden in a pediatric dialysis population. We enrolled 20 patients on hemodialysis (n = 14) and peritoneal dialysis (n = 6) over a period of 12 months. We derived composite scores from selected indices of renal pathology, nutrition, dialysis adequacy, protein catabolism, and dialysis modality. We assessed reliability by a test-retest method and measured validity by defining the relationship of the indices with serum C-reactive protein in a multiple regression analysis. We calculated sensitivity, specificity, accuracy, and precision for the malnutrition-inflammation score. The mean age was 12.8 years (standard deviation = 6.1), and male-female ratio was 12:8. Patients (n = 8) with elevated serum C-reactive protein (>0.3 mg/dL) had higher composite score for malnutrition-inflammation morbidity. Similarly, the pediatric cohort on hemodialys...Continue Reading

References

Feb 20, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K Kalantar-ZadehF C Luft
Jun 28, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bruce A CooperCarol A Pollock
Apr 16, 2003·Kidney International. Supplement·George A Kaysen, Burl R Don
Jan 4, 2005·Blood Purification·Peter Stenvinkel, Bengt Lindholm
Apr 14, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ann Marie McKennaDenis F Geary
Jun 5, 2008·Nature Clinical Practice. Nephrology·Mehdi RambodKamyar Kalantar-Zadeh
Mar 2, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ilia BeberashviliJoshua Weissgarten
Mar 5, 2010·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Ramanath DukkipatiKamyar Kalantar-Zadeh
Jan 18, 2011·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Shuchi AnandGeorge A Kaysen
Mar 21, 2012·Artificial Organs·Marina Avramovic, Vladisav Stefanovic
Jul 25, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lesley Rees, Helen Jones
Apr 19, 2013·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Katarzyna Kiliś-PstrusińskaDanuta Zwolińska
Jun 15, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nur CanpolatRukshana Shroff
Sep 6, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Antonio MastrangeloAlberto Edefonti
Feb 8, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alison G AbrahamSusan L Furth
Feb 19, 2014·Current Opinion in Pediatrics·Elizabeth G Ingulli, Robert H Mak
Mar 8, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Daniela ImpellizzeriSalvatore Cuzzocrea
Apr 11, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bradley A WaradyFranz Schaefer

❮ Previous
Next ❯

Citations

Jul 6, 2018·Frontiers in Pediatrics·Franca M Iorember

❮ Previous
Next ❯

Software Mentioned

Excel
PD ADEQUEST

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
Bariş AfşarN F Ozdemir
Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
Bariş AfşarMehmet Haberal
© 2022 Meta ULC. All rights reserved