PIM1-catalyzed CBX8 phosphorylation promotes the oncogene-induced senescence of human diploid fibroblast

Biochemical and Biophysical Research Communications
Xiangwen ZhanWenhua Yu

Abstract

The proto-oncogene PIM1 encodes Ser/Thr kinase and regulates cell growth, differentiation and apoptosis. However, more and more studies including ours have found that PIM1 can induce senescence in normal human diploid fibroblasts and behave as a tumor suppressor. But the relevant molecular mechanism of this process is not yet clear. It has been reported that Chromobox homolog 8 (CBX8) binds directly to INK4A as a transcriptional repressor, thereby suppressing stress-induced senescence. Here we report that PIM1 can phosphorylate CBX8 to promote its degradation, thereby up-regulating p16, during PIM1-induced cell senescence. Overexpression of CBX8 can inhibit PIM1-induced cell senescence. These data suggest that to promote CBX8 degradation may be an important molecular mechanism of PIM1-induced cell senescence.

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Citations

Nov 20, 2019·Proteomics·Marie-Veronique Clement, Le Luo
Jul 14, 2021·Molecules and Cells·Hyun Jeong KimSang-Beom Seo
Oct 1, 2021·Cell Proliferation·Byeong Hyeok ChoiWei Dai

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