PIM1 kinase is destabilized by ribosomal stress causing inhibition of cell cycle progression.

Oncogene
V IadevaiaFabrizio Loreni

Abstract

PIM1 is a constitutively active serine/threonine kinase regulated by cytokines, growth factors and hormones. It has been implicated in the control of cell cycle progression and apoptosis and its overexpression has been associated with various kinds of lymphoid and hematopoietic malignancies. The activity of PIM1 is dependent on the phosphorylation of several targets involved in transcription, cell cycle and apoptosis. We have recently observed that PIM1 interacts with ribosomal protein (RP)S19 and cosediments with ribosomes. Defects in ribosome synthesis (ribosomal stress) have been shown to activate a p53-dependent growth arrest response. To investigate if PIM1 could have a role in the response to ribosomal stress, we induced ribosome synthesis alterations in TF-1 and K562 erythroid cell lines. We found that RP deficiency, induced by RNA interference or treatment with inhibitor of nucleolar functions, causes a drastic destabilization of PIM1. The lower level of PIM1 induces an increase in the cell cycle inhibitor p27(Kip1) and blocks cell proliferation even in the absence of p53. Notably, restoring PIM1 level by transfection causes a recovery of cell growth. Our data indicate that PIM1 may act as a sensor for ribosomal stress ...Continue Reading

References

Oct 11, 1993·Nucleic Acids Research·P W LairdM Hooper
May 29, 2002·Oncogene·Richard A Steinman
Jun 18, 2002·Current Opinion in Cell Biology·Alessandro Fatica, David Tollervey
Dec 11, 2002·The Journal of Biological Chemistry·Julie A LosmanPaul B Rothman
Mar 4, 2003·Nature Reviews. Cancer·Davide Ruggero, Pier Paolo Pandolfi
Feb 8, 2005·The International Journal of Biochemistry & Cell Biology·Malte Bachmann, Tarik Möröy
Mar 18, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Koichi MiyakeStefan Karlsson
Mar 31, 2005·Molecular Cancer Research : MCR·Kate Petersen ShayNancy S Magnuson
Oct 6, 2005·Cell Cycle·Christine Mayer, Ingrid Grummt
Aug 2, 2006·Molecular and Cellular Biology·Inês SoeiroEric W-F Lam
Dec 8, 2006·Molecular & Cellular Proteomics : MCP·Stefania OrrùIrma Dianzani
Jan 25, 2007·Cell Cycle·Linda PanićSinisa Volarević
Jul 22, 2008·Nature Genetics·Kelly A McGowanGregory S Barsh
Aug 22, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nilesh ShahManuel Salto-Tellez
May 15, 2009·The FEBS Journal·Sara CaldarolaFabrizio Loreni
Oct 16, 2009·Cell Cycle·Michelle D LarreaJoyce M Slingerland

❮ Previous
Next ❯

Citations

Jan 15, 2014·The International Journal of Biochemistry & Cell Biology·Gnaneshwar V YadavNaoya Kenmochi
Jan 1, 2014·Cancer Metastasis Reviews·A de Las Heras-RubioM E LLeonart
Sep 26, 2012·Expert Opinion on Drug Discovery·Naoko OgawaAkiko Tanaka
Oct 1, 2011·Wiley Interdisciplinary Reviews. RNA·Anirban ChakrabortyNaoya Kenmochi
Jan 1, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Azura AmidYumi Zuhanis Has-Yun Hashim
Dec 9, 2014·Nucleus·Allison JamesPatrick DiMario
Mar 8, 2013·RNA Biology·Michela A DentiPaolo Macchi
Jan 29, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wanyeon KimBuHyun Youn
Oct 14, 2016·Scientific Reports·Giada JuliFabrizio Loreni
Jan 1, 2012·Cells·Karl Holmberg OlaussonMikael S Lindström
Nov 13, 2018·Journal of Cellular Physiology·Ghader MolaviElaheh Zadeh Hosseingholi
Jan 30, 2018·Frontiers in Plant Science·Iwai Ohbayashi, Munetaka Sugiyama
Jan 28, 2012·Cancer Research·Giulio DonatiMassimo Derenzini
Sep 24, 2015·Disease Models & Mechanisms·Nadia Danilova, Hanna T Gazda
Oct 26, 2021·Frontiers in Cell and Developmental Biology·Chong ZhangHonghui Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis