Abstract
Emerging evidence has shown that the PIM serine/threonine kinase family, including PIM1, PIM2 and PIM3, is associated with tumour progression towards metastasis. PIM1, an attractive molecular target, has been identified as a potential prognostic biomarker for haematological and epithelial malignancies. However, to date, the potential regulatory roles and molecular mechanisms by which PIM1 affects the development and progression of cancers, including clear-cell renal-cell carcinoma (ccRCC), remain largely unknown. Herein, we present the first evidence that PIM1 is aberrantly overexpressed in human ccRCC tissues and cell lines and positively correlated with human ccRCC progression. In our study, depletion of PIM1 attenuated ccRCC cell proliferation, colony formation, migration, invasion and angiogenesis, suggesting that PIM1 expression may be a cancer-promoting event in ccRCC. Mechanistically, we observed that PIM1 could interact with Smad2 or Smad3 in the nucleus and subsequently phosphorylate Smad2 and Smad3 to induce the expression of transcription factors, including ZEB1, ZEB2, Snail1, Snail2 and Twist, to promote epithelial-mesenchymal transition (EMT). In addition, PIM1-mediated phosphorylation of c-Myc activates the expres...Continue Reading
References
May 28, 1993·Science·F LatifL Geil
Aug 24, 2001·Nature·S M DhanasekaranA M Chinnaiyan
Jun 26, 2002·Oncogene·Maria J BlancoM Angela Nieto
Jun 18, 2003·Cell·Yigong Shi, Joan Massagué
Nov 25, 2003·The Journal of Urology·Igor FrankHorst Zincke
Jun 24, 2004·Cell·Jing YangRobert A Weinberg
Jul 8, 2005·Nature·Derek C RadiskyMina J Bissell
Sep 9, 2005·Nature Reviews. Cancer·Thomas BrabletzThomas Kirchner
Dec 16, 2005·Nature·Napoleone Ferrara, Robert S Kerbel
Mar 28, 2006·The Journal of Biological Chemistry·Gareth P ElvidgeJonathan M Gleadle
Feb 26, 2008·Nature Cell Biology·Muh-Hwa YangKou-Juey Wu
Apr 29, 2008·Oncogene·Y ZhangN S Magnuson
May 20, 2008·Cell·Sendurai A ManiRobert A Weinberg
May 21, 2008·Cancer·Christopher J KanePeter R Carroll
Jul 19, 2008·Human Reproduction·M CohenP Bischof
Aug 19, 2008·Cancer Biology & Therapy·Carolin Reiser-ErkanJörg Kleeff
Oct 17, 2008·Nature Reviews. Cancer·William G Kaelin
Jun 2, 2009·Oncogene·J ChenM H Lee
Feb 9, 2010·Oncogene·J WangS A Abdulkadir
Sep 9, 2010·Nature·Gideon BollagKeith Nolop
Dec 28, 2010·European Urology·Hendrik Van PoppelRichard Sylvester
Jul 28, 2011·International Journal of Cancer. Journal International Du Cancer·Christina Scheel, Robert A Weinberg
Oct 4, 2011·Oncogene·L CaoD Matei
Jan 31, 2012·Oncogene·A L SmithH L Ford
Feb 4, 2012·Cold Spring Harbor Perspectives in Biology·Paola NisticòDerek C Radisky
Mar 1, 2012·Oncogene·Y-N LiuK Kelly
May 9, 2012·PloS One·Patricia Molina-OrtizAmparo Cano
Dec 1, 2012·Current Opinion in Oncology·Yoko KatsunoRik Derynck
Jan 25, 2013·Nature Reviews. Cancer·Bram De Craene, Geert Berx
Feb 26, 2013·Oncogene·C BraeutigamJ Winter
Jun 25, 2013·Nature·UNKNOWN Cancer Genome Atlas Research Network
Feb 22, 2014·Nature Reviews. Molecular Cell Biology·Samy LamouilleRik Derynck
Jul 6, 2014·Molecular Oncology·Parul Gupta, Sanjay K Srivastava
Aug 27, 2014·Neuro-oncology·Susann HerzogSandra Bien-Möller
Jan 1, 2015·Journal of Experimental & Clinical Cancer Research : CR·Xin ZhuMing-hua Ge
Dec 10, 2015·Cancer Medicine·Pengxiang LiJalpa A Doshi
Jan 20, 2016·Scientific Reports·Tianze ZhangLinyou Zhang
Mar 21, 2016·Experimental Eye Research·Chueh-Wei WuYa-Wen Cheng
Jul 2, 2016·Cell·M Angela NietoJean Paul Thiery
Nov 1, 2016·Nature Medicine·Fara Brasó-MaristanyAndrew N Tutt
Dec 31, 2016·Cancer Biomarkers : Section a of Disease Markers·Yunsheng GuoYimin Wang
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 31, 2017·Molecular Oncology·Karen HanrahanR William Watson
Feb 16, 2017·International Journal of Oncology·Amany Sayed MawasYukio Takeshima
Aug 5, 2017·Journal of Cancer·Ting LiYing-Yi Li
Nov 6, 2017·Cancer Biomarkers : Section a of Disease Markers·Qicai LiXiaohui Wang
Citations
Sep 13, 2019·Science Translational Medicine·Ann LinJason M Sheltzer
Feb 8, 2020·Journal of Cellular and Molecular Medicine·Yuxin YangDongdong Lu
Feb 12, 2020·Oncogene·Sean P KennedyBryan T Hennessy
Apr 16, 2020·Molecular Cancer·Maureen LabbéDelphine Fradin
Jun 20, 2020·The Journal of Pathology·Ming-Sum LeungRegina Cheuk-Lam Lo
Apr 17, 2019·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Xueqiang GaoHaibo Wang
Jul 19, 2018·Journal of Experimental & Clinical Cancer Research : CR·Xiupeng XuJing Ji
Jun 10, 2020·Cell Death & Disease·Xin LvZhonghua Wei
Oct 22, 2020·International Journal of Molecular Sciences·Erna Marija MeškytėYari Ciribilli
Mar 17, 2020·Cardiovascular Research·David E EbeidMark A Sussman
Sep 4, 2020·Molecular Therapy. Nucleic Acids·Peng WangFan Fan Hou
May 3, 2021·Clinical Epigenetics·L J SmythA J McKnight
May 19, 2021·In Vitro Cellular & Developmental Biology. Animal·Hua XiaYajun Xie
Oct 19, 2020·Current Cancer Drug Targets·Milad AshrafizadehManoj Garg
Aug 28, 2021·Biomedicines·Ekaterina Mikhailovna StasevichAnton Markovich Schwartz
Nov 20, 2021·Frontiers in Cell and Developmental Biology·Wan-Lin LiuQing-Hai Ji