Pimobendan in heart failure therapy--a silver bullet?

Journal of the American Animal Hospital Association
Sonya G GordonAshley B Saunders

Abstract

Pimobendan is a novel agent with properties that are highly desirable in the clinical management of congestive heart failure (CHF) secondary to both dilated cardiomyopathy (DCM) and chronic degenerative valvular disease in dogs. Review of available data suggests that pimobendan is safe, well tolerated, and leads to enhanced quality of life in dogs with CHF secondary to DCM or chronic valvular disease when used in combination with furosemide or other conventional therapies (e.g., angiotensin-converting enzyme inhibitors, digoxin). Pimobendan leads to a reduction in mortality from CHF associated with DCM, and ongoing studies are evaluating its effects on mortality associated with chronic valvular disease.

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Citations

May 23, 2012·Journal of the American Animal Hospital Association·L Noelani ReinkerMark Rishniw
Jan 16, 2009·Journal of Veterinary Internal Medicine·M OuelletG Beauchamp
Apr 2, 2015·Chemical Communications : Chem Comm·Tiago RodriguesGisbert Schneider
Aug 26, 2014·Journal of the American Veterinary Medical Association·Yamir Reina-DoresteKathryn M Meurs
Nov 23, 2019·Mini Reviews in Medicinal Chemistry·Mahesh S VasavaHitesh D Patel
Jun 23, 2021·Journal of the American Heart Association·Jordan E MorningstarRussell A Norris

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