Pin1 modulates chemo-resistance by up-regulating FoxM1 and the involvements of Wnt/β-catenin signaling pathway in cervical cancer

Molecular and Cellular Biochemistry
Tao WangJiquan Wang

Abstract

The prolyl isomerase Pin1, which is frequently highly expressed in many different cancers, can directly regulate cell proliferation and the cell cycle. However, the role of Pin1 in chemo-resistance remains to be elucidated in cervical cancer. The purpose of the present study was to investigate the role of Pin1 in the chemo-resistance of cervical cancer. The cisplatin resistance was assessed using the MTT assay. Pin1, FoxM1, β-catenin, Cyclin D1, and c-myc expression levels were detected by RT-qPCR or Western blot. The results showed that Pin1 expression displayed a similar expression pattern with the resistance to cisplatin in five cervical cell lines. Knockdown of Pin1 significantly increased the sensitivity to cisplatin in HeLa cells, while Pin1 overexpression decreased the sensitivity to cisplatin in Me180 cells. Knockdown of Pin1 significantly down-regulated FoxM1 expression in HeLa cells, while Pin1 overexpression showed a contrary effect in Me180 cells. Besides, overexpression of Pin1 markedly increased the protein expression of β-catenin and its target genes cyclin D1 and c-myc. FoxM1 siRNA remarkably reversed the promotory effect of pcDNA-Pin1(+) on β-catenin and its target genes cyclin D1 and c-myc in Me180 cells. Furt...Continue Reading

References

Jul 2, 2003·Nature Reviews. Cancer·Roshan Agarwal, Stan B Kaye
Apr 28, 2004·The American Journal of Pathology·Lere BaoDa-Gong Wang
Aug 27, 2005·World Journal of Gastroenterology : WJG·Chang-Jae KimWon-Sang Park
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Akihide RyoIchiro Aoki
May 3, 2006·Molecular Carcinogenesis·Kun Ping LuGerburg Wulf
Oct 19, 2007·Nature Reviews. Cancer·Stephen S Myatt, Eric W-F Lam
Feb 26, 2008·Nature Reviews. Cancer·Stephen S Myatt, Eric W-F Lam
Dec 17, 2009·Cancer Biology & Therapy·Xiaogang TanJie He
Jan 14, 2010·Molecular Cancer Research : MCR·Jimmy M-M KwokEric W-F Lam
Mar 24, 2011·The Cancer Journal·Valentina FodaleEmanuel Petricoin
Apr 14, 2011·Expert Opinion on Therapeutic Targets·Hisayuki YaoTaira Maekawa
Sep 6, 2011·Oncogene·L GalluzziG Kroemer
Oct 8, 2011·Biochimica Et Biophysica Acta·Chuay-Yeng KooEric W-F Lam
Mar 1, 2012·Current Pharmaceutical Design·Jiujie CuiKeping Xie
Mar 23, 2012·Cold Spring Harbor Perspectives in Biology·Paul Polakis
Nov 28, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yu WangWen-chao Liu
Oct 16, 2013·Gynecologic Oncology·Rebecca C ArendDonald J Buchsbaum
Jul 2, 2014·Nature Reviews. Drug Discovery·Michael Kahn
Aug 16, 2014·Cell Research·Zhimin Lu, Tony Hunter

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Citations

Mar 17, 2017·Journal of Cellular Biochemistry·Afsane BahramiAmir Avan
Sep 28, 2017·Cell Biology International·Rafael P de CamposMárcia R Wink
Aug 31, 2016·Archives of Pharmacal Research·Sang-Hyun MinKun Ping Lu
Jan 6, 2018·Biomedicines·Ilya O VelegzhaninovOlesya M Vakhrusheva
Apr 8, 2020·Frontiers in Cell and Developmental Biology·Ji Hoon YuSang-Hyun Min
Oct 27, 2018·International Journal of Molecular Sciences·Duc-Hiep BachSang Kook Lee
Jun 14, 2019·World Journal of Pediatrics : WJP·Li Gu, Han-Min Liu
Aug 8, 2020·Biological Research·Bingqi WangMin Wang
Apr 9, 2020·Frontiers in Cell and Developmental Biology·Xiangming Hu, Lin-Feng Chen
Aug 31, 2018·Cell Death & Disease·Yang ChenYing-Bin Yang
May 17, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Guoliang FanShaoting Liu
Nov 16, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S G KhoeiR Najafi
Feb 6, 2018·Oncology Letters·Argyrios SklavosDimitrios Giakoustidis
Apr 4, 2021·Biomedicines·Hsiang-Hao ChuangChih-Jen Yang
Oct 26, 2016·Bioorganic & Medicinal Chemistry·Hailong ZhaoBailing Xu

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