PMID: 19288014Mar 17, 2009Paper

Pin1 overexpression is associated with poor differentiation and survival in oral squamous cell carcinoma

Oncology Reports
Kam-Wing LeungPei-Jung Lu

Abstract

Phosphorylation on certain Ser/Thr-Pro motifs is a major oncogenic mechanism. The conformation and function of phosphorylated Ser/Thr-Pro motifs are further regulated by the prolyl isomerase Pin1. Pin1 has been shown to be prevalently overexpressed in human breast cancer cell lines and cancer tissues and to play a critical role in the transformation of mammary epithelial cells by activating multiple oncogenic pathways. Pin1 expression was found to be an excellent independent prognostic marker in prostate cancer. However, little is known about Pin1 and its downstream targets beta-catenin and cyclin D1 expressions in human oral cancers. In the present study, we quantified Pin1 expression in 74 paired normal/tumor human oral cancer samples as well as oral cancer cell lines. Pin1 was overexpressed in oral squamous cell carcinoma (OSCC) and its level correlated with beta-catenin accumulation and cyclin D1 expression. Moreover, we examined Pin1 mRNA expression in OSCC and cancer cell lines by RT-PCR analysis. The results showed that there is concordance in the relationship between the Pin1 mRNA level and Pin1 protein expression. The up-regulation of Pin1 mRNA expression in tumor part when comparing with that in non-tumor part was in ...Continue Reading

Citations

Jan 12, 2011·Thyroid Research·Andrzej LewińskiAnna Cyniak-Magierska
Jan 8, 2011·Head & Neck Oncology·Anna G ZygogianniVassilis Kouloulias
Nov 20, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Javier GirardiniGiannino Del Sal
Oct 1, 2011·Journal of Cellular Biochemistry·Kozue Sakao, Shivendra V Singh
Sep 3, 2013·Biochimica Et Biophysica Acta·Yu-Chyi HwangWinston C Y Yu
Apr 21, 2017·PloS One·Maria Solange IbarraJavier Girardini
Jun 21, 2011·Expert Reviews in Molecular Medicine·Tae Ho LeeKun Ping Lu

Related Concepts

Squamous Cell Carcinoma
Cell Differentiation Process
Cell Survival
Immunocytochemistry
Malignant Neoplasm of Mouth
Peptidylprolyl Isomerase
Cyclin D1
Beta catenin
Biological Markers
Malignant Neoplasm of Breast

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