Pinacidil pretreatment improves vascular reactivity after shock through PKCα and PKCε in rats

Journal of Cardiovascular Pharmacology
Jing XuLiangming Liu

Abstract

We investigated the beneficial effect of pinacidil pretreatment on vascular reactivity, calcium sensitivity, and animal survival after hemorrhagic shock, its relationship to protein kinase Cα (PKCα), protein kinase Cε (PKCε), and adenosine. Using hemorrhagic shock rats, the protective effects of different extents of pinacidil pretreatment on vascular reactivity and in which the roles of PKCα, PKCε, and adenosine were observed. Pinacidil pretreatment significantly improved shock-induced decrease of vascular reactivity of superior mesenteric artery, which was antagonized by the PKCα antagonist Gö-6976 (5 × 10 mole/L) and PKCε pseudosubstrate inhibitory peptide (1 × 10 mole/L). Pinacidil pretreatment induced the translocation of PKCα and PKCε from the cytoplasm to the membrane. This translocation of PKCα and PKCε was eliminated by adenosine A1 receptor antagonist DPCPX (1 × 10 mole/L). As compared with simple fluid resuscitation, combination with pinacidil pretreatment significantly improved the vascular reactivity and survival rate of hemorrhagic-shocked rats. These results suggested that pinacidil pretreatment could induce good protective effects on vascular reactivity and calcium sensitivity after hemorrhagic shock mainly throu...Continue Reading

References

Jul 1, 1987·Journal of Clinical Pharmacology·M C Rijk, T Thien
Aug 1, 1995·Journal of Molecular and Cellular Cardiology·S C ArmstrongC E Ganote
Sep 2, 1999·The Journal of Thoracic and Cardiovascular Surgery·N MatsudaF W Sellke
May 4, 2000·The Journal of Surgical Research·J FengE R Rosenkranz
Sep 2, 2000·The Annals of Thoracic Surgery·G R GaudetteS Levitsky
Sep 29, 2000·Pharmacology & Therapeutics·J W de JongS Bradamante
May 12, 2001·Il Farmaco·E OnginiP G Baraldi
Mar 20, 2003·The Journal of Surgical Research·Jun FengEliot R Rosenkranz
May 17, 2003·European Journal of Medicinal Chemistry·Pier Giovanni BaraldiPier Andrea Borea
Sep 5, 2003·European Journal of Pharmacology·John R FozardCedric Wolber
Nov 25, 2006·Brain : a Journal of Neurology·José F Téllez-ZentenoSamuel Wiebe
Apr 17, 2007·Heart·Erik B Friedrich, Michael Böhm
May 23, 2007·Heart Failure Reviews·James M DowneyMichael V Cohen
Nov 14, 2007·Basic Research in Cardiology·Michael V Cohen, James M Downey
Jan 21, 2010·Cell·Christina KielLuis Serrano
Aug 3, 2010·Journal of Vascular Surgery·Nilon ErlingLuiz Francisco Poli-de-Figueiredo
Oct 16, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Thorsten M SmulFranz Kehl

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Citations

Mar 8, 2013·Immunopharmacology and Immunotoxicology·Kwang Sik SuhEun Mi Choi
Oct 22, 2014·Molecular Medicine Reports·Eun Mi ChoiKwang Sik Suh

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