Pinealectomy abolishes circadian behavior and interferes with circadian clock gene oscillations in brain and liver but not retina in a migratory songbird

Physiology & Behavior
Amit K TrivediVinod Kumar

Abstract

In songbirds, the pineal gland is part of the multi-oscillatory circadian timing system, with participating component oscillators in the eyes and hypothalamus. This study investigated the role of the pineal gland in development of the nighttime migratory restlessness (Zugunruhe) and generation of circadian gene oscillations in the retina, brain and liver tissues in migratory redheaded buntings (Emberiza bruniceps). Pinealectomized (pinx) and sham-operated buntings entrained to short days (8h light: 16h darkness, 8L:16D) were sequentially exposed for 10days each to stimulatory long days (13L: 11D) and constant dim light (LLdim; a condition that tested circadian rhythm persistence). Whereas activity-rest pattern was monitored continuously, the mRNA expressions of clock genes (bmal1, clock, npas2, per2, cry1, rorα, reverα) were measured in the retina, hypothalamus, telencephalon, optic tectum and liver tissues at circadian times, CT, 1, 6, 13, 17 and 21 (CT 0, activity onset) on day 11 of the LLdim. The absence of the pineal gland did not affect the development of long-day induced Zugunruhe but caused decay of the circadian rhythm in Zugunruhe as well as the clock gene oscillations in the hypothalamus, but not in the retina. Furth...Continue Reading

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Citations

Nov 2, 2016·Molecular Ecology·Rachel A JohnstonThomas B Smith
Jun 14, 2017·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Tyler J Stevenson, Vinod Kumar
Oct 27, 2018·Chronobiology International·Zothanmawii RenthleiAmit Kumar Trivedi
Mar 30, 2018·Journal of the Royal Society, Interface·Atticus Pinzon-RodriguezRachel Muheim
Mar 17, 2017·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Verner P Bingman, Scott A MacDougall-Shackleton
Jun 18, 2021·Scientific Reports·Atticus Pinzon-Rodriguez, Rachel Muheim
May 5, 2021·Molecular Biology and Evolution·Daiqing YinGuang Yang

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