Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration

The Journal of Cell Biology
Laura E Newman, Gerald S Shadel

Abstract

What causes inflammation in age-related neurodegenerative diseases remains a mystery. Sliter et al. (2018. Nature https://doi.org/10.1038/s41586-018-0448-9) show that, when damaged mitochondria cannot be removed by mitophagy, stress from exercise or mitochondrial DNA mutations activates the proinflammatory cGAS-STING pathway that may contribute to Parkinson's disease.

References

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Aug 24, 2018·Nature·Danielle A SliterRichard J Youle

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Citations

Apr 17, 2020·Biological Chemistry·Verian Bader, Konstanze F Winklhofer
Jun 14, 2019·Frontiers in Cellular and Infection Microbiology·Kristin L PatrickRobert O Watson
Sep 26, 2020·Frontiers in Microbiology·Zhihua RenJunliang Deng
Jun 30, 2019·Disease Models & Mechanisms·Lucie ValekIrmgard Tegeder
Oct 6, 2020·IScience·Johannes BurtscherGrégoire P Millet
Feb 19, 2021·Frontiers in Cell and Developmental Biology·Cara R SchiavonUri Manor
Jun 12, 2021·Trends in Cancer·Eileen WhiteJessie Yanxiang Guo
Jul 6, 2021·RSC Medicinal Chemistry·Silke Miller, Maria-Jesus Blanco
Jun 14, 2021·Behavioral and Brain Functions : BBF·Aliabbas ZiaSaeed Samarghandian
Aug 3, 2021·Frontiers in Cell and Developmental Biology·Longping YaoGuohui Lu
Aug 17, 2020·Neuroscience·Yi-Qun YanBao-Rong Zhang
Aug 4, 2021·The Journal of Cell Biology·Himanish BasuThomas L Schwarz
Oct 15, 2021·Journal of Neuroinflammation·Shawn Hayley, Hongyu Sun
Oct 20, 2021·Journal of Molecular Cell Biology·Juli Bai, Feng Liu

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Methods Mentioned

BETA
gene knock-outs

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