Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications.

Chemical Science
Maria WeberTony D James

Abstract

Reaction-based fluorescent-probes have proven successful for the visualisation of biological species in various cellular processes. Unfortunately, in order to tailor the design of a fluorescent probe to a specific application (i.e. organelle targeting, material and theranostic applications) often requires extensive synthetic efforts and the synthetic screening of a range of fluorophores to match the required synthetic needs. In this work, we have identified Pinkment-OH as a unique "plug-and-play" synthetic platform that can be used to develop a range of ONOO- responsive fluorescent probes for a variety of applications. These include theranostic-based applications and potential material-based/bioconjugation applications. The as prepared probes displayed an excellent sensitivity and selectivity for ONOO- over other ROS. In vitro studies using HeLa cells and RAW 264.7 macrophages demonstrated their ability to detect exogenously and endogenously produced ONOO-. Evaluation in an LPS-induced inflammation mouse model illustrated the ability to monitor ONOO- production in acute inflammation. Lastly, theranostic-based probes enabled the simultaneous evaluation of indomethacin-based therapeutic effects combined with the visualisation of ...Continue Reading

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Citations

Jan 14, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Minmin WangJin Wang
Apr 20, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xi-Le HuDaijie Chen
Oct 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiao-Bo WangYan-Chao Wu

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