PMID: 15245196Jul 13, 2004Paper

Pinning of tumoral growth by enhancement of the immune response

Physical Review Letters
Antonio BrúIsabel Brú

Abstract

Tumor growth is a surface phenomenon of the molecular beam epitaxy universality class in which diffusion at the surface is the determining factor. This Letter reports experiments performed in mice showing that these dynamics can, however, be changed. By stimulating the immune response, we induced strong neutrophilia around the tumor. The neutrophils hindered cell surface diffusion so much that they induced new dynamics compatible with the slower quenched-disorder Edwards-Wilkinson universality class. Important clinical effects were also seen, including remarkably high tumor necrosis (around 80%-90% of the tumor), a general increase in survival time [the death ratio in the control group is 15.76 times higher than in the treated group (equivalent to a Cox's model hazard ratio of 0.85; 95% confidence interval 0.76-0.95, p=0.004)], and even the total elimination of some tumors.

References

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May 6, 1991·Physical Review Letters·Z Lai, Das Sarma S
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Oct 29, 2003·Biophysical Journal·Antonio BrúIsabel Brú

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Citations

Apr 26, 2007·Bulletin of Mathematical Biology·Svetlana Bunimovich-MendrazitskyLewi Stone
Oct 6, 2007·Medical Oncology·Antonio BrúEduardo López-Collazo
Aug 7, 2009·Cytokine & Growth Factor Reviews·William K Decker, Amar Safdar
Aug 8, 2006·Journal of Theoretical Biology·A Brú, D Casero
Jun 5, 2014·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Ronit Vogt SionovZvi Granot
Mar 24, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·G J SibonaS Cossy Isasi
Oct 13, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Joaquim FortNeus Isern
Jun 4, 2008·Physical Review Letters·Carlos Escudero
Oct 15, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·S A Menchón, C A Condat
Oct 30, 2015·Journal of the Royal Society, Interface·H HatzikirouM Meyer-Hermann
Sep 19, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Tibor AntalM A Nowak
Apr 12, 2006·Physical Review Letters·Yiping ChenH Eugene Stanley
Oct 10, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Carlos Escudero
Jun 13, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·M RadszuweitD Drasdo
Feb 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Alexander S BalankinMaribel A Mendoza
Apr 12, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Carlos Escudero
Sep 28, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Yong-Jun ChenKenichi Yoshikawa

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