Pinocembrin reduces cardiac arrhythmia and infarct size in rats subjected to acute myocardial ischemia/reperfusion

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Anusorn LungkaphinNipon Chattipakorn

Abstract

Oxidative stress plays an important role in the pathogenesis of ischemia/reperfusion (I/R) injury induced by cardiac dysfunction. Pinocembrin (5,7-dihydroxyflavanone) is a flavonoid found in propolis and in rhizomes of fingerroot (Boesenbergia pandurata) that is reported to have pharmacological properties including antimicrobial, antioxidant, and anti-inflammatory activities. The cardioprotective effects of pinocembrin in an I/R model were investigated in this study. Male Wistar rats (n = 20) were randomly divided into 2 groups to receive either pinocembrin (30 mg/kg body weight) or the vehicle intravenously. Thirty minutes later, the left anterior descending coronary artery of each rat was ligated for 30 min, and then reperfusion was allowed for 120 min. Cardiac function improved in the pinocembrin-treated group: the time to first ventricular fibrillation (VF) was significantly longer in the treated group (550 ± 54 s) than in the vehicle-only control group (330 ± 27 s) (p < 0.05). VF incidence and arrhythmia score were lower and infarcts were 49% smaller in the pinocembrin-treated group than in the control group (p < 0.05). In the pinocembrin-treated group, malondialdehyde levels and Bax/Bcl-2 ratios decreased, and the ratio o...Continue Reading

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Citations

Jun 2, 2016·BMC Cardiovascular Disorders·Xing-Han TianMeng Chen
Jun 2, 2016·Canadian Journal of Physiology and Pharmacology·Sasivimon PromsanAnusorn Lungkaphin
Sep 20, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yufen LiChangli Lou
Sep 10, 2020·Frontiers in Pharmacology·Nonhlakanipho F SangweniRabia Johnson
Nov 13, 2020·Oxidative Medicine and Cellular Longevity·Yanjun ZhengJingrong Lin
Jan 8, 2021·Biology·Henrique SilvaAntónio Raposo
Apr 20, 2021·Dose-response : a Publication of International Hormesis Society·Farshid AbediSaeed Samarghandian

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