PMID: 11905203Jun 1, 1968Paper

Pinocytotic response of circulating erythrocytes to specific blood grouping antibodies

The Journal of Cell Biology
P L BlantonS Haberman

Abstract

Human blood samples from adults and newborns of blood groups O, A, and B were treated with either anti-A blood grouping serum, ferritin-conjugated anti-A serum, free ferritin, or saline and then prepared for electron microscopy. Morphological differences were observed between the untreated erythrocytes of infants and adults. Circulating red cells of newborns were frequently vesiculated (25.5%), whereas those of adults only occasionally showed vesicles (5.5%). On the basis of morphology and incidence, the majority of these vesiculated cells seemed to be mature erythrocytes. The introduction of anti-A serum to group A erythrocytes of infants appeared to stimulate vesicle formation, but anti-A serum did not have a similar effect on group O or B cells of infants or on group A cells of adults. Vesicles which formed in response to antiserum treatment appeared to be the result of pinocytosis. In contrast to the well dispersed ferritin along the membrane of agglutinated adult cells, the ferritin particles on the infants' cells were frequently clustered at irregular intervals. These accumulations seemed to lead to invaginations of the cell membrane, resulting in ferritin-lined intracytoplasmic vesicles. The addition of free ferritin or ...Continue Reading

References

Oct 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·H Z MovatT Uriuhara
Dec 1, 1965·The Journal of Cell Biology·H Z MovatJ F Mustard
Dec 1, 1965·Journal of Ultrastructure Research·D OrlicJ A Rhodin
Feb 1, 1967·Journal of Ultrastructure Research·I Berman
May 25, 1957·The Journal of Biophysical and Biochemical Cytology·M C BESSIS, J BRETON-GORIUS
Aug 1, 1962·The Journal of Cell Biology·J A GRASSOG A ACKERMAN
Nov 1, 1964·The Journal of Cell Biology·R E LEE, J D FELDMAN
Feb 1, 1965·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J M MARSHALL, V T NACHMIAS

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Citations

Feb 1, 1975·The Anatomical Record·A C Cordier
Sep 4, 1969·The New England Journal of Medicine·C P HolroydeF H Gardner
Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R G PainterS J Singer
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R Schekman, S J Singer
Jun 2, 2011·The Journal of Infectious Diseases·Joseph HorzempaGerard J Nau
Dec 1, 1974·British Journal of Haematology·O Gasko, D Danon
Mar 19, 2008·Transfusion·Giel J C G M BosmanWillem J De Grip
Jul 1, 1972·The Journal of Clinical Investigation·I Ben-BassatS L Schrier
Nov 1, 1972·Archives of Biochemistry and Biophysics·J T Penniston
Apr 1, 1988·American Journal of Hematology·W H Reinhart, S Chien
Aug 1, 1988·American Journal of Hematology·R H SillsC A Glomski
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·S E ZweigS J Singer

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