Pinpoint papular variant of polymorphous light eruption: clinical and pathological correlation

Journal of the European Academy of Dermatology and Venereology : JEADV
I BansalA Ormsby

Abstract

Polymorphous light eruption (PMLE) is the most common chronic idiopathic photodermatosis usually manifesting as a papular eruption along with several other morphological variants including a pinpoint papular variant. Between June 1998 and August 2003, 10 PMLE patients presented to the Department of Dermatology at Henry Ford Hospital with complaints of a pruritic pinpoint papular eruption associated with sun exposure. In six patients skin biopsies were performed along with a detailed history and complete skin examination. We correlated the histology with the clinical course of disease corresponding to acute and subacute disease presentation. We also performed immunohistochemistry on three cases to study the immunophenotype in PMLE. The clinical, histologic and immunostain findings are summarized. Acute: Clinically pinpoint papules and vesicles, some with erythematous base, were seen. Histology showed focal vesicle formation, spongiosis, oedema, red blood cells extravasation, and superficial and deep perivascular and interstitial lymphocytic infiltrate with occasional eosinophils. Subacute: Clinically pinpoint papules with or without erythema were seen. Histology of the pinpoint lesion showed a nodular collection of lymphocytes a...Continue Reading

References

Feb 1, 1989·The British Journal of Dermatology·P G NorrisJ L Hawk
Jun 1, 1984·Journal of the American Academy of Dermatology·B MoncadaR Urbina
Feb 1, 1983·The British Journal of Dermatology·J E MuhlbauerM C Mihm
Apr 1, 1994·International Journal of Dermatology·M C Van PraagB J Vermeer
Jan 22, 2003·Photodermatology, Photoimmunology & Photomedicine·Andrew P KontosHenry W Lim

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Citations

Mar 12, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yi-An Chen, Julia Yu-Yun Lee
Dec 22, 2015·Clinics in Dermatology·Michael J PayetteKristen E Holland
Mar 19, 2009·Photodermatology, Photoimmunology & Photomedicine·Lynn Y T Chiam, Wei-Sheng Chong
Jun 14, 2013·Clinical and Experimental Dermatology·A R WadhwaniB K Khaitan
Jun 12, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·D GutierrezE N Pritchett
Nov 6, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Vinod Kumar SharmaAshok Roopchand Wadhwani
Oct 23, 2021·Dermatologic Therapy·Miroslava KadurinaGeorgeta Bocheva
May 8, 2021·Indian Dermatology Online Journal·Kaliaperumal Karthikeyan, Manju Aishwarya

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