Pioglitazone Ameliorates Gentamicin Ototoxicity by Affecting the TLR and STAT Pathways in the Early Postnatal Organ of Corti

Frontiers in Cellular Neuroscience
Marijana Sekulic-JablanovicDaniel Bodmer

Abstract

Noise trauma, infection, and ototoxic drugs are frequent external causes of hearing loss. With no pharmacological treatments currently available, understanding the mechanisms and pathways leading to auditory hair cell (HC) damage and repair is crucial for identifying potential pharmacological targets. Prior research has implicated increased reactive oxygen species (ROS) and inflammation as general mechanisms of hearing loss common to diverse causes. Novel targets of these two key mechanisms of auditory damage may provide new paths toward the prevention and treatment of hearing loss. Pioglitazone, an oral antidiabetic drug from the class of thiazolidinediones, acts as an agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-γ) and is involved in the regulation of lipid and glucose metabolism. PPAR-γ is an important player in repressing the expression of inflammatory cytokines and signaling molecules. We evaluated the effects of pioglitazone in the mouse Organ of Corti (OC) explants to characterize its influence on signaling pathways involved in auditory HC damage. The OC explants was cultured with pioglitazone, gentamicin, or a combination of both agents. Pioglitazone treatment resulted in significant repression ...Continue Reading

References

Nov 27, 1995·Biochemical Pharmacology·E M Priuska, J Schacht
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·B LiuK Shuai
Aug 5, 2004·Journal of Biomedicine & Biotechnology·Jihan Youssef, Mostafa Badr
Oct 7, 2004·Hearing Research·Keiji TakemuraToshio Yamashita
Jan 24, 2006·Journal of Neuroscience Research·Masato FujiokaHideyuki Okano
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Ramya KapadiaRaghu Vemuganti
Mar 26, 2009·Experimental Neurology·Jennifer C RobertsAndrew D Medhurst
Mar 24, 2010·Annual Review of Immunology·Kenneth L RockHajime Kono
Dec 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gi-Su OhHong-Seob So
Jan 5, 2011·The Journal of Biological Chemistry·Toru KubotaKeiko Ozato
Nov 6, 2013·Journal of Medicinal Chemistry·Francesco Peri, Valentina Calabrese
Jul 17, 2014·Immunology and Cell Biology·Kevin LuuAshley Mansell
Oct 4, 2014·Frontiers in Pharmacology·Takayuki Nakagawa
Oct 15, 2014·Journal of Neuroinflammation·Qunfeng CaiBo Hua Hu
Dec 30, 2015·PPAR Research·Amanda CroasdellRichard P Phipps
Jun 3, 2016·Cell Death & Disease·R R VethanayagamB H Hu
Apr 28, 2017·Frontiers in Cellular Neuroscience·Megan B Wood, Jian Zuo

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
cochlear microdissections
Chip
Protein Assay
nuclear translocation
RNAseq
sumoylation

Key Resources (RRID) Mentioned

AB_2099233
AB_330924

Software Mentioned

Illumina RTA
QuasR package
win
RNA
edgeR
R
STAR
GraphPad Prism
GraphPad Outlier calculator
Basecalling

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cell Fate Conversion By mRNA

mRNA-based technology is being studied as a potential technology that could be used to reprogram cell fate. This technique provides the potential to generate safe reprogrammed cells that can be used for clinical applications. Here is the latest research on cell fate conversion by mRNA.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Yoshimasa Aso
Nihon rinsho. Japanese journal of clinical medicine
Hiroyoshi Yokoi
JPMA. the Journal of the Pakistan Medical Association
Sanjay Kalra, Yashdeep Gupta
Nihon rinsho. Japanese journal of clinical medicine
Masashi KobayashiKazuyuki Hiratani
International Journal of Clinical Practice. Supplement
P Brunetti
© 2021 Meta ULC. All rights reserved