Pioglitazone increases circulating microRNA-24 with decrease in coronary neointimal hyperplasia in type 2 diabetic patients- optical coherence tomography analysis

Circulation Journal : Official Journal of the Japanese Circulation Society
Soon Jun HongDo-Sun Lim

Abstract

Aberrant expression of microRNAs is associated with neointimal hyperplasia (NIH) in type 2 diabetes. We prospectively compared the effects of pioglitazone on coronary NIH and changes in microRNAs according to NIH status in type 2 diabetic patients during 9-month follow-up. Type 2 diabetic patients were randomly assigned to the pioglitazone (n=36) or control groups (n=36) after coronary stenting. Primary endpoint was the comparison of changes in neointimal volume on OCT and in the level of circulating microRNA-17,-24,-92a,-126 and -145 during 9-month follow-up. Secondary endpoint was the comparison of changes in brachial artery flow-mediated dilation and inflammatory markers such as IL-6, TNF-α, hsCRP, adiponectin, sICAM-1, and sVCAM-1 between the 2 groups. Neointimal volume was significantly lower in the pioglitazone group (25.02±17.78 mm(3)vs. 55.10±30.01 mm(3), P<0.001) with significant increases in circulating microRNA-24 (0.264±0.084 vs. 0.006±0.030, P<0.001) during follow-up. FMD was significantly greater in the pioglitazone than control group at 9 months (0.47±0.14 mm vs. 0.28±0.18 mm, P<0.05, respectively). Decreases in inflammatory markers such as IL-6, TNF-α, and sVCAM-1 were significantly greater in the pioglitazone t...Continue Reading

References

Apr 29, 2004·JAMA : the Journal of the American Medical Association·James B MeigsJoAnn E Manson
Mar 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Soon Jun HongChang Gyu Park
Jul 8, 2010·European Heart Journal·Stefanie Dimmeler, Andreas M Zeiher
Sep 4, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Soon Jun HongDo-Sun Lim
Mar 9, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Tomotaka DohiHiroyuki Daida
Oct 21, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Stephan FichtlschererStefanie Dimmeler
Jan 21, 2012·Journal of Cellular and Molecular Medicine·Jue WangZhe Zheng
Mar 8, 2012·Korean Circulation Journal·Kyu-Young ChoiJae-Hyung Kim
Jul 17, 2012·Journal of Vascular Research·Karine TréguerStefanie Dimmeler
Nov 24, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Aramesh SaremiPeter D Reaven
Mar 19, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Richard E Gilbert
Sep 26, 2013·BioMed Research International·Andrew AdvaniRichard E Gilbert
Oct 11, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Wai San CheangXiao Yu Tian
Feb 14, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Salvatore De RosaCiro Indolfi
May 17, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Reinier A Boon, Stefanie Dimmeler
Jul 6, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Karina Di GregoliJason L Johnson
Jul 16, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Masamichi IwasakiKen-ichi Hirata
Sep 13, 2014·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Rémy HanfBart Staels

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Citations

Dec 23, 2015·European Journal of Clinical Pharmacology·Marko StojanovićMiroslav Radenković
Mar 6, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshiro Shinke
Jul 15, 2015·Diabetologia·Juliette RaffortEmmanuel Van Obberghen
Mar 1, 2018·Heart and Vessels·Atsushi TanakaUNKNOWN Pioglitazone Reduce Inflammation and Restenosis with and without Drug Eluting Stent (PRIDE) Study Investigators
Oct 17, 2019·International Journal of Molecular Sciences·Hong Sheng ChengNguan Soon Tan
Mar 17, 2017·BioMed Research International·Yue DingPeng-Fei Shan
May 20, 2021·Cardiovascular Diabetology·Lorenzo NestiAndrea Natali

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