Pioglitazone insulin sensitivity and type 2 diabetes mellitus: recent data

Annales d'endocrinologie
L Monnier, J-P Sauvanet

Abstract

Thiazolidinediones ("glitazones") were recently added to the oral treatment of type 2 diabetes. Two glitazones are available in France, pioglitazone and rosiglitazone, which progressively were granted broader therapeutic indications since their launch in 2002. This review presents the most recent pioglitazone pharmacological and clinical data, with a particular emphasis on the QUARTET clinical study program results. Available information generates perspectives and hopes: prevention of the progressive decline in beta-pancreatic cell function (and possibly, prevention of type 2 diabetes in at-risk subjects), cardiovascular prevention in type 2 diabetic patients depending on the results of the ongoing prospective morbi-mortality studies in high risk type 2 diabetic patients.

References

Mar 1, 1992·Diabetes Care·R A DeFronzoE Ferrannini
Nov 5, 1997·American Journal of Hypertension·T A KotchenH Y Zhang
Jun 26, 1998·Journal of Cardiovascular Pharmacology·M R GralinskiM A Breider
Mar 4, 1999·Diabetologia·J D McGarry, R L Dobbins
May 14, 1999·Trends in Endocrinology and Metabolism : TEM·M J Reginato, M A Lazar
Sep 13, 2000·Drugs·P S Gillies, C J Dunn
Oct 24, 2000·Trends in Endocrinology and Metabolism : TEM·J M Olefsky, A R Saltiel
Nov 30, 2000·Biochemical and Biophysical Research Communications·J SakamotoH Sawada
Feb 24, 2001·Annals of Internal Medicine·A A ParulkarV A Fonseca
Mar 7, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·C K Glass
Jun 20, 2001·Diabetes, Obesity & Metabolism·A J Stears, C D Byrne
Jul 10, 2001·The Journal of Clinical Endocrinology and Metabolism·H KoshiyamaY Nakamura
Aug 9, 2001·Coronary Artery Disease·S RosenblattUNKNOWN Pioglitazone 026 Study Group
Oct 5, 2001·Metabolism: Clinical and Experimental·T NakamuraH Koide
Sep 17, 2002·The American Journal of Cardiology·Harold E Lebovitz
Jul 29, 2003·Diabetes Care·Manju ChandranRobert R Henry
Dec 11, 2003·Diabetologia·A GastaldelliUNKNOWN San Antonio metabolism study

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Citations

Jun 17, 2005·Annales d'endocrinologie·J Girard

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