Pioglitazone use and Parkinson's disease: a retrospective cohort study in Taiwan

BMJ Open
Hsiu-Feng WuSenyeong Kao

Abstract

Many researchers have expected pioglitazone to serve as an effective neuroprotective agent against Parkinson's disease (PD). Therefore, we conducted this cohort study to investigate the association between pioglitazone use and PD by using a large Asian population-based dataset in Taiwan. Retrospective cohort study. Taiwan. 7906 patients with diabetes who had received pioglitazone were defined as the study cohort, and 7906 matched patients with diabetes who had not received pioglitazone were defined as the comparison cohort. We tracked each patient individually over a 5-year follow-up period to identify those diagnosed as having PD during this period. We performed Cox proportional hazard regression analyses to evaluate the HRs for PD between the study and comparison cohorts. The findings indicated that among the sampled patients, PD occurred in 257 (1.63%): 119 (1.51%) pioglitazone users and 138 (1.75%) non-users. The adjusted HR for PD within the follow-up period was 0.90 (95% CI: 0.68 to 1.18) in the patients who had received pioglitazone compared with the matched patients who had not received pioglitazone. Moreover, this study revealed that pioglitazone use was not associated with PD incidence in men (HR: 1.06, 95% CI: 0.71 t...Continue Reading

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Citations

Jun 10, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Salman HussainBenny Antony
Jul 12, 2020·Antioxidants·Kuo-Hsuan Chang, Chiung-Mei Chen
Mar 17, 2020·Journal of Neural Transmission·John D Elsworth
Sep 25, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y-Hu ChangK-D Lin
May 30, 2021·Brain Research Bulletin·Kambiz HassanzadehMarco Feligioni

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