Pioglitazone use and risk of bladder cancer: a systematic literature review and meta-analysis of observational studies

Diabetology International
Juha MehtäläFabian Hoti

Abstract

Studies investigating bladder cancer risk in pioglitazone-treated type 2 diabetes mellitus patients report conflicting results. Previous meta-analyses on this topic utilized publications prior to 2013. More long-term observational studies have been published since then. We reviewed the accumulated evidence and updated findings from previous meta-analyses. This meta-analysis was based on a systematic review of peer-reviewed observational studies published prior to September 30, 2016. Eligible studies were identified using a specified MEDLINE search. References from included studies and from previous meta-analyses were screened for additional records. Meta-analysis hazards ratios were derived using a random-effects model. Several sensitivity analyses including hierarchical Bayesian meta-analysis with country-specific effects were conducted. Of 363 identified records, 23 studies were included in this review and 18 in the actual meta-analyses. For bladder cancer outcome, the estimated effect size for ever vs. never use of pioglitazone was 1.16 [95% confidence interval (CI), 1.04-1.28]. In the cumulative dose and duration analyses, highest effect was observed in the highest/longest exposure group, but substantial heterogeneity was p...Continue Reading

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Citations

Nov 14, 2019·Endocrine Reviews·Iliana C Lega, Lorraine L Lipscombe
Jan 7, 2020·Diabetes & Metabolism Journal·Sunghwan Suh, Kwang Won Kim
Feb 12, 2021·Nature Reviews. Gastroenterology & Hepatology·Raj VuppalanchiArun J Sanyal
Jun 2, 2021·Current Opinion in Cardiology·Michael P JohnstonChristopher D Byrne

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