Pioglitazone vs glimepiride: Differential effects on vascular endothelial function in patients with type 2 diabetes

Atherosclerosis
Katerina PapathanassiouLampros K Michalis

Abstract

The aim of this study was to compare the effect of glimepiride and pioglitazone on endothelial function in patients with type 2 diabetes already on metformin. Twenty-eight patients with type 2 diabetes already on metformin, without known cardiovascular disease, were randomized in 2 groups; glimepiride (4 mg od) was added in group A (n=14) and pioglitazone (30 mg od) in group B (n=14) for 6 months. Flow-mediated dilation (FMD) in the brachial artery was assessed in all patients, at baseline and at follow-up. The 2 groups did not differ in age (mean+/-S.D., 63.6+/-7.3 years vs 62.8+/-7.2 years respectively), or any measured variable at baseline. Fasting glucose and glycated haemoglobin improved similarly in both groups. There were significant differences between the 2 groups in the absolute changes observed at follow-up in waist circumference, +1.86+/-3.11 cm vs -1.86+/-1.88 cm in groups A and B respectively; fasting insulin levels, +14.79+/-12.56 pmol/L vs -25.84+/-28.09 pmol/L; homeostasis model assessment (HOMA), +0.66+/-1.01 vs -1.83+/-1.38; HDL cholesterol levels, -0.07+/-0.22 mmol/L vs +0.14+/-0.20 mmol/L and FMD, +0.14+/-1.09% vs +2.02+/-2.05% (p<0.05 for all). The only independent predictor factor of the FMD improvement w...Continue Reading

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Citations

Aug 17, 2010·The International Journal of Cardiovascular Imaging·Naser AhmadiMatthew J Budoff
Sep 12, 2012·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Xuemei YuTong Zhu
Oct 16, 2012·Cardiovascular Diabetology·Katerina K NakaLampros K Michalis
Feb 19, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Katerina K NakaLampros K Michalis
Apr 2, 2011·European Journal of Pharmacology·Lu-Lu ChenHong-cheng Ding
May 1, 2010·Journal of Cardiovascular Computed Tomography·Naser AhmadiMatthew Budoff
Apr 19, 2013·Diabetes, Obesity & Metabolism·M MonamiE Mannucci
Apr 14, 2012·International Journal of Vascular Medicine·M MoerlandJ Burggraaf
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Nov 13, 2009·Diabetes Care·Daniele VersariStefano Taddei
Nov 4, 2011·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Katerina K NakaLampros K Michalis
May 18, 2011·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Katerina K NakaLampros K Michalis
Feb 7, 2018·Frontiers in Cardiovascular Medicine·Nikoletta Pechlivani, Ramzi A Ajjan
Jan 22, 2019·Current Medicinal Chemistry·Anastasios TentolourisNikolaos Tentolouris
May 20, 2021·Cardiovascular Diabetology·Lorenzo NestiAndrea Natali

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