Pioneer Factors and Architectural Proteins Mediating Embryonic Expression Signatures in Cancer

Trends in Molecular Medicine
Stephanie DoberschGuillermo Barreto

Abstract

Accumulation of mutations causing aberrant changes in the genome promotes cancer. However, mutations do not occur in every cancer subtype, suggesting additional events that trigger cancer. Chromatin rearrangements initiated by pioneer factors and architectural proteins are key events occurring before cancer-related genes are expressed. Both protein groups are also master regulators of important processes during embryogenesis. Several publications demonstrated that embryonic gene expression signatures are reactivated during cancer. This review article highlights current knowledge on pioneer factors and architectural proteins mediating chromatin rearrangements, which are the backbone of embryonic expression signatures promoting malignant transformation. Understanding chromatin rearrangements inducing embryonic expression signatures in adult cells might be the key to novel therapeutic approaches against cancers subtypes that arise without genomic mutations.

References

Jun 1, 1990·Gynecologic Oncology·V KukuraB Hrdina
Apr 16, 1998·The Journal of Biological Chemistry·E P RogakouW M Bonner
Feb 11, 1999·Critical Reviews in Oncogenesis·A Mansouri
Jul 13, 2000·Molecular and Cellular Biology·L J WoodL M Resar
Aug 23, 2003·Science·Rimma BelotserkovskayaDanny Reinberg
Feb 3, 2005·Genes & Development·Rohinton T Kamakaka, Sue Biggins
Aug 5, 2006·Developmental Biology·Kimberly DeckerLori Sussel
Aug 16, 2006·Cellular and Molecular Life Sciences : CMLS·J R Friedman, K H Kaestner
Dec 26, 2006·Nature Cell Biology·Marie-Liesse Asselin-LabatJane E Visvader
Mar 28, 2007·Nature Reviews. Genetics·Patrick P L Tam, David A F Loebel
May 18, 2007·Current Pharmaceutical Design·Gal GoldsteinArnon Nagler
Oct 10, 2007·The Journal of Biological Chemistry·Mitsutoki Hatta, Lisa Ann Cirillo
Nov 28, 2007·Biochemical and Biophysical Research Communications·Noritaka YamaguchiShinya Watanabe
Jan 19, 2008·Journal of Biosciences·Chunjiang HeRongjia Zhou
Mar 11, 2008·Cell·Dustin E SchonesKeji Zhao
Apr 10, 2008·Cell Stem Cell·David J WongHoward Y Chang
Feb 11, 2009·Nature Reviews. Genetics·Cizhong Jiang, B Franklin Pugh
Apr 21, 2009·Nature Medicine·Matina EconomopoulouTriantafyllos Chavakis
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Debby M E I HellebrekersManon van Engeland
Sep 15, 2009·Biochimica Et Biophysica Acta·Raymond Reeves
Dec 17, 2009·Biochimica Et Biophysica Acta·Gabi Gerlitz
Dec 15, 2010·Nature Genetics·Antoni HurtadoJason S Carroll
Dec 21, 2010·Immunity·Yann M KerdilesStephen M Hedrick
Jan 15, 2011·Genome Research·Aurélien A SérandourJérôme Eeckhoute
Jan 26, 2011·Cell Research·Emmanuelle SzenkerGeneviève Almouzni
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg

❮ Previous
Next ❯

Citations

Aug 12, 2020·Proceedings of the National Academy of Sciences of the United States of America·Cheng Tan, Shoji Takada
Aug 5, 2020·Genes & Development·James A Heslop, Stephen A Duncan
Mar 11, 2021·Molecular Cell·Elizabeth D LarsonMelissa M Harrison
Aug 14, 2021·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Menghua ZhangShumpei Ishikawa
Dec 24, 2021·Nature·Lanbo XiaoArul M Chinnaiyan
Sep 9, 2021·British Journal of Cancer·Xiangyu ChenYongguang Tao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved