Abstract
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that eventually leads to severe cognitive impairment. Although the exact etiologies of AD still remain elusive, increasing evidence suggests that neuroinflammation cascades mediated by microglial cells are associated with AD. Piper sarmentosum Roxb. (PS) is a medicinal plant reported to possess various biological properties, including anti-inflammatory, anti-psychotic and anti-oxidant activity. However, little is known about the anti-inflammatory activity of PS roots despite their traditional use to treat inflammatory- mediated ailments. This study aimed to evaluate the anti-inflammatory and neuroprotective properties of extracts obtained from the roots of PS against beta-amyloid (Aβ)-induced microglial toxicity associated with the production of pro-inflammatory mediators. BV2 microglial cells were treated with hexane (RHXN), dichloromethane (RDCM), ethyl acetate (REA) and methanol (RMEOH) extracts of the roots of PS prior to activation by Aβ. The production and mRNA expression of pro-inflammatory mediators were evaluated by Griess reagent, ELISA kits and RT-qPCR respectively. The phosphorylation status of p38α MAPK was determined via western blot assay. BV...Continue Reading
References
Apr 12, 2001·Journal of Ethnopharmacology·J R StöhrR Bauer
Nov 5, 2003·Biochemistry·Brett A ChromyWilliam L Klein
Jul 6, 2004·Journal of Ethnopharmacology·Thitima RukachaisirikulApichart Suksamrarn
Feb 8, 2006·Chemical & Pharmaceutical Bulletin·Pittaya TuntiwachwuttikulWalter Charles Taylor
Dec 7, 2007·Chemical Research in Toxicology·Lawrence M SayreMark A Smith
Oct 29, 2009·Planta medica·Khalid HussainPazilah Ibrahim
Dec 29, 2009·Journal of Ethnopharmacology·Z A ZakariaM R Sulaiman
Mar 9, 2010·CNS & Neurological Disorders Drug Targets·Shweta Mandrekar-Colucci, Gary E Landreth
Mar 18, 2010·Nature Reviews. Neurology·V Hugh PerryClive Holmes
May 6, 2010·Journal of Zhejiang University. Science. B·Abdul Hamid HafizahAbdullah Mahdy Zaleha
Jul 30, 2010·Clinics·Azizah UgusmanNor Anita Megat Mohd Nordin
Apr 19, 2011·International Immunopharmacology·Fu Qian HeHua Tian Gan
Jul 8, 2011·Journal of Neuroinflammation·Adam D BachstetterLinda J Van Eldik
Oct 25, 2011·Cytokine & Growth Factor Reviews·Gloria Lopez-Castejon, David Brough
Dec 21, 2013·Cell Death & Disease·B ParajuliA Suzumura
May 24, 2014·Neuron·Tara L Spires-Jones, Bradley T Hyman
Oct 1, 2014·PloS One·Rita AldiniRoberta Budriesi
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·John J Alam
Oct 29, 2015·Journal of Neurochemistry·Myles R MinterPeter J Crack
Apr 8, 2016·Translational Neurodegeneration·Cong ZhengJian-Zhi Wang
Jan 28, 2017·Journal of Ethnopharmacology·Qing LiLu-Ping Qin
Aug 3, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jong Kil Lee, Nam-Jung Kim
Feb 21, 2018·Journal of Ethnopharmacology·Emilia Tze Ying YeoElaine Wan Ling Chan
Citations
Dec 4, 2019·Current Topics in Medicinal Chemistry·Iván CarreraRamón Cacabelos
May 28, 2019·International Journal of Molecular Sciences·Carmen Infante-Garcia, Monica Garcia-Alloza
Mar 26, 2021·Current Alzheimer Research·Elaine Wan Ling ChanSook Yee Gan
Apr 22, 2021·CNS & Neurological Disorders Drug Targets·Himanshi Varshney, Yasir Hasan Siddique
Jul 28, 2019·Life Sciences·Kim San Tang