Piperazine derivatives with central pharmacological activity used as therapeutic tools

Fundamental & Clinical Pharmacology
Adriane F BritoElson A Costa

Abstract

Medicinal chemistry is a science applied to the search and discovery of new therapeutic agents for the treatment of various diseases. Therefore, promising structures have been identified; one of these structures is the piperazine moiety, a cyclic molecule containing two nitrogen atoms in positions 1 and 4 as well as four carbon atoms. Many piperazine derivatives have central pharmacological activity that mainly involves the activation of the monoamine pathway. Thus, piperazine derivatives have been the subject of research for many central therapeutic applications, including antipsychotic, antidepressant and anxiolytic applications. Benzylpiperazine is the prototype of piperazine derivatives; this substance is the main component of recreational drugs, partly due to its stimulant and euphoric effects. This paper describes some piperazine derivatives used therapeutically as antipsychotic (clozapine), antidepressant (vortioxetine) and anxiolytic (buspirone) drugs.

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Citations

Oct 23, 2019·Acta Crystallographica. Section E, Crystallographic Communications·Haruvegowda Kiran KumarChristopher Glidewell
Aug 17, 2019·Acta Crystallographica. Section E, Crystallographic Communications·Haruvegowda Kiran KumarChristopher Glidewell
Apr 14, 2020·Acta Crystallographica. Section E, Crystallographic Communications·Haruvegowda Kiran KumarChristopher Glidewell
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Dec 19, 2020·Drug Research·Akash JainAshwani Dhingra
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Mar 21, 2021·Environmental Science and Pollution Research International·Bijo MathewHoon Kim
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Jul 31, 2020·Behavioural Brain Research·Lorrane Kelle MoreiraElson Alves Costa
Jun 4, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Run-Hui ZhangZhe-Shan Quan

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