Piperine treating sciatica through regulating inflammation and MiR-520a/P65 pathway.

Chinese Journal of Natural Medicines
Jiu-Wang YuLu Wang

Abstract

Although the etiology of sciatica remains uncertain, there is increasing evidence that the disease process of sciatica is associated with the levels of inflammatory factors. Piperine, an alkaloid isolated from Piper nigrum, has previously been demonstrated to inhibit inflammation and analgesic effects. The purpose of this study is to verify the regulatory relationship between miR-520a and p65 and to explore how miR-520a/P65 affects the level of cytokines under the action of piperine, so as to play a therapeutic role in sciatica. Through ELISA experiment, we confirmed that four inflammatory factors (IL-1β, TNF-α, IL-10, TGF-β1) can be used as evaluation indexes of sciatica. The differentially expressed miRNA was screened as miR-520a, by microarray technology, and the downstream target of miR-520a was P65 by bioinformatics. Real-time fluorescence quantitative PCR confirmed that the expression of miR-520a was negatively correlated with pro-inflammatory cytokines, positively correlated with anti-inflammatory cytokines and negatively correlated with p65 expression at mRNA level. The expression of p65 was positively correlated with pro-inflammatory cytokines and negatively correlated with anti-inflammatory cytokines at the protein le...Continue Reading

References

May 5, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Gowhar ShafiAnjana Munshi
Sep 7, 2017·Neurosurgery·Ziev B Moses, John H Chi
Mar 6, 2018·Frontiers in Pharmacology·Abeer K MalkawiAnas M Abdel Rahman
Mar 22, 2018·Frontiers in Immunology·Afsar R NaqviSalvador Nares
Apr 5, 2018·The Journal of International Medical Research·Bulin BaiyilaTengfei Long
Apr 21, 2018·Journal of the American College of Cardiology·Grant W ReedSteven E Nissen
Apr 25, 2018·The FEBS Journal·Charlotte NejadMichael P Gantier
Jun 2, 2018·Journal of Cellular Physiology·Saife Niaz LoneMahboob Ul Hussain
Jun 22, 2018·World Neurosurgery·Mark A PacultAbhay K Varma
Aug 23, 2018·Journal of Cellular Physiology·Donghua XuShushan Yan
Nov 28, 2018·Journal of Cellular Physiology·Rana ShafabakhshZatollah Asemi
May 30, 2019·Journal of Cellular Physiology·Feng TangBing Zhao
Jul 6, 2019·Journal of Cellular Physiology·Amirsaeed S AghabozorgiAlireza Pasdar
Jul 31, 2019·Phytotherapy Research : PTR·Ui-Hyun ParkSoo-Jong Um
Aug 30, 2019·Reumatologia·Piotr WojdasiewiczAgnieszka Paradowska-Gorycka
Aug 30, 2019·Journal of Immunotoxicology·Cris KamperschroerMichael D Eisenbraun

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