Piracetam and fipexide prevent PTZ-kindling-provoked amnesia in rats

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
M G Genkova-Papazova, M Lazarova-Bakarova

Abstract

Deficit in active and inhibitory avoidance behaviour has been pentylenetetrazole (PTZ)-kindled rats. This supports the view that memory deficit is an integral part of epilepsy. In the present study we examined the effect of the nootropic drugs piracetam and fipexide on memory deficit induced by PTZ-kindling in shuttle-box- and step-down-trained rats. The retention in piracetam- and fipexide-treated animals was significantly improved compared to the kindled controls. The mechanisms of action of the two drugs are considered. The favourable of nootropic drugs in cases of amnesia provoked by PTZ-kindling might be of interest in clinical practice.

References

Jan 1, 1992·Behavioral and Neural Biology·A BeckerH Matthies
Jul 1, 1991·Pharmacology, Biochemistry, and Behavior·G GreckschH Matthies
Nov 1, 1990·Peptides·G A OlsonA J Kastin
Jan 1, 1988·Trends in Neurosciences·J O McNamara
Jan 1, 1986·Acta Neurologica Scandinavica. Supplementum·C Mondadori, M Schmutz
Jan 1, 1986·Acta Neurologica Scandinavica. Supplementum·C A Hawkins, J H Mellanby
Jan 1, 1986·Acta Neurologica Scandinavica. Supplementum·J Majkowski
Jan 16, 1986·Neuroscience Letters·F H Lopes da SilvaW J Wadman
Jan 1, 1983·Psychopharmacology·G ChouinardF Fontaine
Mar 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·P J Thompson, M R Trimble
Mar 1, 1995·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M G Genkova-Papazova, M B Lazarova-Bakarova
Sep 1, 1994·The European Journal of Neuroscience·A BeckerM Brosz
May 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·A BeckerH Matthies
Dec 1, 1993·Neuropsychologia·I JambaquéJ L Signoret
Nov 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·N Kapur
Apr 1, 1993·Progress in Neurobiology·J S HongC L Mitchell

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Citations

Jun 29, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M G Genkova-PapazovaM Lazarova-Bakarova
Apr 21, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M G Genkova-PapazovaM Lazarova-Bakarova
Jul 20, 2005·Clinical and Experimental Pharmacology & Physiology·Ashish DhirShrinivas K Kulkarni
Jul 5, 2006·Biological & Pharmaceutical Bulletin·Enver AltasYavuz Sutbeyaz
Jun 20, 2007·Rapid Communications in Mass Spectrometry : RCM·Lekha SlenoGérard Hopfgartner
Mar 12, 2013·Pharmacology, Biochemistry, and Behavior·Suelen A NavarroWaldiceu A Verri
Oct 30, 2001·Evolution; International Journal of Organic Evolution·R C FleischerC M Wemmer

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