PMID: 108722Mar 14, 1979

Piracetam facilitates retrieval but does not impair extinction of bar-pressing in rats

Psychopharmacology
S J SaraC Giurgea

Abstract

Rats were trained on a continuously reinforced bar-press response for water reward. Seven days later they were retested for retention, with or without pretest injection of the nootropic drug, piracetam. Drug-treated animals had significantly shorter response latencies than saline-treated animals. The results are interpreted as a facilitation of retrieval processes after forgetting. The experiment was extended under extinction conditions and it was found that after three sessions there was a tendency to facilitate extinction when response latency is used as the extinction index. The clinical interest of a drug which facilitates the retrieval aspect of the memory process without impairing extinction is discussed.

References

Jul 1, 1975·Journal of Comparative and Physiological Psychology·S J SaraD Lefevre
Sep 1, 1974·Psychological Review·P E Gold, R A King
May 1, 1974·Pharmacology, Biochemistry, and Behavior·C Y Botwinick, D Quartermain
Nov 14, 1970·Nature·E K Warrington, L Weiskrantz
May 1, 1972·Psychological Medicine·G Edwards

Citations

Jan 1, 1986·Annals of Dyslexia·C R Wilsher
Sep 1, 1979·Pharmacology, Biochemistry, and Behavior·L S FreedmanD Quartermain
May 1, 1986·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·C R Wilsher
Jan 1, 1995·Journal of Psychopharmacology·N H Allen, A Burns
May 1, 2003·Expert Review of Neurotherapeutics·Ruediger Mielke, Brigitte Szelies

Related Concepts

Metazoa
Operant Conditioning
Extinction, Psychological
Memory
Sinapsan
Pyrrolidinones
Experimental Water Deprivation
Rats, Laboratory

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