PirB functions as an intrinsic suppressor in hippocampal neural stem cells.

Aging
Baiyang LiuCuiping Yang

Abstract

Neural stem cells play pivotal roles during prenatal development and throughout life. Here, we report that Paired immunoglobulin-like receptor B (PirB) functions as a suppressor during brain neurogenesis in the adult mouse. PirB expression increased with age during development, and its deficiency promoted neural stem cell proliferation and differentiation in vivo and in vitro. Furthermore, we detected an increase in Type 1 neural stem cells in PirB-deficient mice compared to their wild-type littermates. PirB deficiency promoted stemness marker gene expression of Sox2 and KLF4 by activating Akt1 phosphorylation. These findings suggest that PirB inhibits the self-renewal and differentiation capacities of neural stem cells. Thus, PirB may have the potential to serve as a therapeutic target for treatment of reduced neurogenesis in adults due to aging or other pathological conditions.

References

Aug 28, 1965·Nature·J Altman, G D Das
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·H KubagawaM D Cooper
Jan 20, 1999·The Journal of Experimental Medicine·H KubagawaM D Cooper
May 22, 2002·Nature Immunology·Azusa UjikeToshiyuki Takai
Sep 11, 2003·Developmental Neuroscience·Tobi L LimkeMark P Mattson
Aug 26, 2004·The Journal of Biological Chemistry·Nicholas R D PalingMelanie J Welham
Jul 19, 2005·Annual Review of Neuroscience·Guo-li Ming, Hongjun Song
Aug 19, 2006·Science·Josh SykenCarla J Shatz
May 22, 2007·Nature Reviews. Neuroscience·Elizabeth Gould
Feb 26, 2008·Cell·Chunmei ZhaoFred H Gage
Nov 8, 2008·Science·Jasvinder K AtwalMarc Tessier-Lavigne
Oct 21, 2009·Neuron·Pamela A Carpentier, Theo D Palmer
Mar 3, 2011·The EMBO Journal·Yuki FujitaToshihide Yamashita
May 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kojo AritaToshiyuki Takai
Sep 2, 2011·Development·Cui-Ping YangSteven G Kernie
Feb 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael FrickerGuy C Brown
Mar 27, 2012·Neuron·Jaimie D AdelsonRona G Giffard
May 9, 2012·Journal of Molecular Neuroscience : MN·Heather D VanGuilder StarkeyWillard M Freeman
Apr 23, 2013·Journal of Neuroscience Research·A GiannakopoulouG C Papadopoulos
Jan 23, 2014·Stem Cells·Srinivas RamasamySohail Ahmed
Apr 19, 2015·Stem Cell Research·Elias GebaraNicolas Toni
Sep 4, 2015·Cold Spring Harbor Perspectives in Biology·Gerd KempermannFred H Gage
Oct 3, 2015·Cell Stem Cell·Allison M BondHongjun Song
Nov 14, 2016·Journal of the Neurological Sciences·Aline Silva de MirandaAntônio Lúcio Teixeira
Nov 9, 2017·Molecular Medicine Reports·Yong-Yan Bi, Yong Quan
Jul 25, 2019·Advances in Experimental Medicine and Biology·Lindsay M GurskaKira Gritsman

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