PMID: 3116574Jan 1, 1987

Pirenzepine inhibits growth hormone, but not thyrotropin response to thyrotropin-releasing hormone in patients with endogenous depression

V CoiroP Chiodera


In order to evaluate whether in endogenous depression the anomalous growth hormone (GH) response to thyrotropin-releasing hormone (TRH) is mediated by muscarinic cholinergic receptors, 12 patients were tested with TRH (200 micrograms iv) with and without previous treatment with the muscarinic cholinergic receptor blocker pirenzepine (40 mg iv 10 min before TRH). Control tests with normal saline also were performed. Administration of normal saline did not alter serum GH levels. In contrast, TRH injections significantly increased serum GH concentrations by about three-fold. This response was inhibited by pretreatment with pirenzepine. Another neuroendocrine marker of endogenous depression, the low TSH increase in response to TRH (delta less than or equal to 7 microU/ml), was observed in our patients. Pretreatment with pirenzepine did not modify this response. These data indicate that in patients with endogenous depression a muscarinic cholinergic mechanism is involved in the GH response but not in the TSH response to TRH.


Jan 1, 1977·Psychoneuroendocrinology·R C CasperH Dekirmenjian
Oct 1, 1978·Archives of General Psychiatry·F BrambillaE E Müller
Jan 1, 1977·Psychoneuroendocrinology·F GrégoireJ Corvilain
May 1, 1974·The Journal of Clinical Endocrinology and Metabolism·T M SilerR Guillemin
Sep 1, 1982·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·F SalernoE E Müller
Mar 1, 1980·Psychiatry Research·N MatussekB Wasilewski
Dec 1, 1983·The Journal of Clinical Endocrinology and Metabolism·G DelitalaM Mannelli
Sep 1, 1984·The Journal of Clinical Endocrinology and Metabolism·F F CasanuevaA Fernandez-Cruz
Jan 1, 1981·Psychoneuroendocrinology·M S GoldD R Sweeney
Oct 1, 1982·Psychiatry Research·L J SieverD L Murphy
Jan 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·S A CheckleyE Shur
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

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