Pirfenidone: an update on clinical trial data and insights from everyday practice

European Respiratory Review : an Official Journal of the European Respiratory Society
Michael Kreuter

Abstract

Pirfenidone is an orally active, small molecule that inhibits synthesis of profibrotic and inflammatory mediators. It was approved for the treatment of adults with mild-to-moderate idiopathic pulmonary fibrosis in the European Union based on the results of two pivotal phase III, double-blind, randomised, placebo-controlled clinical trials (CAPACITY) demonstrating efficacy and safety, and supported by two Japanese clinical trials (SP2 and SP3). Currently, there is increasing interest in experience with pirfenidone in patients relating to the real-world setting. Following the publication of the CAPACITY clinical studies, additional analyses have been conducted to provide further support for pirfenidone in clinical practice, including a modified per-protocol analysis of the CAPACITY study population. New data from the RECAP extension study also provided longer term data for pirfenidone and promising continuation rates with treatment. Pirfenidone is also being evaluated in specialist centre cohorts providing important information on real-world efficacy and safety. Increasing experience with pirfenidone in everyday clinical practice is helping to establish \expert guidance on the management of known adverse events, together with pra...Continue Reading

Citations

Jan 18, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Wei SunRui-jie Chen
Jun 30, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Annalisa CarlucciGianfranco Butera
Sep 26, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Jinqing HuYuguan Wen
Dec 3, 2014·Revista portuguesa de pneumologia·J M Borro
Sep 2, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·So-Young LeeMary E Choi
Apr 10, 2015·Revista Portuguesa De Pneumologia·J M Borro
May 14, 2016·Expert Opinion on Drug Safety·Adam AndersonSteven D Nathan
Aug 16, 2016·Chest·Ayodeji Adegunsoye, Mary E Strek
Sep 2, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Sergio Harari, Antonella Caminati
Nov 12, 2019·Clinical & Translational Immunology·Andrew McLean-TookeFiona Lake
Aug 4, 2019·Pharmacological Reports : PR·Dalia H El-KashefDina S El-Agamy
Jan 30, 2020·Pharmacological Reports : PR·Dalia H El-KashefDina S El-Agamy

Related Concepts

Deskar
Lung
Pyridones
Phase 3 Clinical Trials
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Evidence-Based Medicine
Idiopathic Pulmonary Fibrosis
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Double-Blind Method

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