Piribedil and pathological gambling in six parkinsonian patients

Arquivos de neuro-psiquiatria
Federico MicheliGabriela B Raina

Abstract

Impulse control disorders (ICD) in Parkinson's disease (PD) have attracted increasing interest. They are characterized by the inability to control the impulse to perform an act that can be detrimental to them or to others. Although dopamine agonists (DA), as a group, have been associated with impulse control disorders (ICD), piribedil has rarely been reported to cause them. Case reports of six parkinsonian patients on piribedil presenting pathological gambling (PG). All of the patients presented ICD associated with piribedil use. Two of them received this medication as first treatment and four of them who had developed ICDs secondary to other DA that reappeared with piribedil. Despite piribedil is commercially available in only a few countries, it should be considered in the differential diagnosis of PG in patients with PD.

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Citations

Mar 1, 2016·Expert Review of Neurotherapeutics·Adolfo Ramirez-ZamoraJosé Biller
Jun 28, 2016·CNS Drugs·Santiago Perez-Lloret, Olivier Rascol
Aug 26, 2016·Expert Opinion on Pharmacotherapy·Fabrizio StocchiChiara Fossati
Sep 2, 2020·Expert Opinion on Drug Safety·Fabrizio StocchiMargherita Torti
Apr 11, 2019·Drugs·Margherita TortiFabrizio Stocchi

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