PMID: 9188653Jul 1, 1997Paper

pIRS1 and pTRS1 are present in human cytomegalovirus virions

Journal of Virology
M J RomanowskiThomas Shenk

Abstract

The virus-coded proteins pIRS1 and pTRS1 were found associated with purified human cytomegalovirus virions. The proteins were not degraded when intact virions were treated with trypsin, which suggests that they are localized inside the viral particle. In transfection experiments pIRS1 and pTRS1 modestly activated expression from a reporter plasmid containing the viral major immediate-early promoter but did not influence the activity of a reporter carrying the irs1/trs1 immediate-early promoter. Both reporters were activated by the combination of pIRS1 or pTRS1 and pUL69, which is also present in virions.

References

Aug 1, 1977·The Journal of General Virology·P Talbot, J D Almeida
Sep 1, 1996·Journal of Virology·C J Baldick, T Shenk

❮ Previous
Next ❯

Citations

Nov 5, 2002·Journal of Virology·Catherine A Blankenship, Thomas Shenk
Apr 30, 2003·Journal of Virology·Carine MénardUlrich H Koszinowski
Dec 13, 2003·Journal of Virology·Stephanie J ChildAdam P Geballe
May 28, 2005·Journal of Virology·Morgan Hakki, Adam P Geballe
Dec 30, 2011·Journal of Virology·Magali ChaumorcelAudrey Esclatine
Jun 8, 2001·Journal of Virology·L A LaPierre, B J Biegalke
Nov 21, 2007·Reviews in Medical Virology·Beatrice MercorelliGiorgio Palù
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Claudia MackWolfram Brune
Jun 7, 2008·Microbiology and Molecular Biology Reviews : MMBR·Robert F Kalejta
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·M L HayashiT Shenk
Feb 26, 2005·Journal of Virology·Zaruhi KarabekianAnn E Campbell
May 25, 2002·The Journal of General Virology·Richard AdairDerrick J Dargan
Dec 3, 2003·The Journal of General Virology·Richard AdairAnamaris M Colberg-Poley
Feb 12, 2002·Journal of Virology·Yingguang Liu, Bonita J Biegalke
Jun 5, 2003·Pharmacology & Therapeutics·Santo LandolfoDavid Lembo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.