Piscine islet xenotransplantation

ILAR Journal
James R WrightJoseph R Leventhal

Abstract

Tilapia, a teleost fish species with large anatomically discrete islet organs (Brockmann bodies; BBs) that can be easily harvested without expensive and fickle islet isolation procedures, make an excellent donor species for experimental islet xenotransplantation research. When transplanted into streptozotocin-diabetic nude or severe combined immunodeficient mice, BBs provide long-term normoglycemia and mammalian-like glucose tolerance profiles. However, when transplanted into euthymic recipients, the mechanism of islet xenograft rejection appears very similar to that of islets from "large animal" donor species such as the very popular fetal/neonatal porcine islet cell clusters (ICCs). Tilapia islets are more versatile than ICCs and can be transplanted (1) into the renal subcapsular space, the cryptorchid or noncryptorchid testis, or intraportally as neovascularized cell transplants; (2) as directly vascularized organ transplants; or (3) intraperitoneally after microencapsulation. Unlike the popular porcine ICCs, BBs function immediately after transplantation; thus, their rejection can be assessed on the basis of loss of function as well as other parameters. We have also shown that transplantation of tilapia BBs into nude mice c...Continue Reading

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Citations

Jul 2, 2004·ILAR Journal·Stephen W Barthold
Jul 2, 2004·ILAR Journal·Juan L ContrerasDevin E Eckhoff
Jul 10, 2007·General and Comparative Endocrinology·Olga HrytsenkoBill Pohajdak
Apr 6, 2005·Xenotransplantation·Ayman Al-JazaeriJames R Wright
Jan 25, 2006·General and Comparative Endocrinology·J H YousonD M Irwin
Jan 18, 2006·General and Comparative Endocrinology·Emily L R AlexanderJames R Wright

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