PMID: 18407138Apr 1, 1993Paper

Pit-1 and hypopituitarism

Trends in Endocrinology and Metabolism : TEM
J S ParksR W Pfaffle

Abstract

The story of Pit-1 and hypopituitarism in humans provides an excellent example of pleiotrophism or multiple phenotypic effects resulting from a single genetic alteration. It shows how defects in this single gene cause the absence o f several pituitary hormones. Three recent articles reviewed here provide examples of different mutations in this homeobox gene encoding a transcriptional activation protein that is vital to the embryologic development, survival, and differentiated function of somatotropes, lactotropes, and thyrotropes.

References

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Citations

Mar 1, 1997·Domestic Animal Endocrinology·R L MatteriF C Buonomo
Jan 1, 1996·Nature Genetics·K E Mayo
Oct 16, 1999·The New England Journal of Medicine·M L Vance, N Mauras
Sep 16, 2014·Diabetes & Metabolic Syndrome·Jostol PintoB M Venkatesha
Mar 1, 1997·Clinical Obstetrics and Gynecology·D A Fisher
Mar 8, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Hadar Haim-PinhasZvi Laron
Jun 19, 1998·American Journal of Medical Genetics·O V FofanovaS Yamashita
Dec 13, 1996·The Journal of Biological Chemistry·M DelhaseE L Hooghe-Peters
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May 1, 1994·Annals of Clinical Biochemistry·J M Burrin
Oct 1, 1994·Current Opinion in Genetics & Development·S J RhodesM G Rosenfeld

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