Pit-1 gene polymorphism, milk yield, and conformation traits for Italian Holstein-Friesian bulls

Journal of Dairy Science
R RenavilleD Portetelle

Abstract

The growth hormone factor-1/pituitary-specific transcription factor Pit-1 is responsible for the expression of growth hormone in mammals. Mutations in Pit-1 have been found in growth hormone disorders of mice and humans. We studied the eventual association between Pit-1 polymorphism using the HinfI enzyme and the milk yield and conformation traits of 89 Italian Holstein-Friesian bulls. A strategy employing polymerase chain reaction was used to amplify a 451-bp fragment from semen DNA. Digestion of polymerase chain reaction products with HinfI revealed two alleles: allele A was not digested (451-bp fragment), and allele B was cut at one restriction site, generating two fragments of 244 and 207 bp. Three patterns were observed; frequencies were 2.2, 31.5, and 66.3% for AA, AB, and BB, respectively. Fixed and mixed linear models were fitted on daughter yield deviations for milk yields and on deregressed proofs for conformation traits. Predictions were weighted using the inverse of the estimated variance of records. The models used contained mean and gene substitution effects for Pit-1 A allele as fixed effects and random sire effect for the mixed model. The A allele was found to be superior for milk and protein yields, inferior fo...Continue Reading

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Citations

Jul 9, 2008·Animal Biotechnology·L F MartinsJ A Visintin
Apr 17, 2009·Animal Biotechnology·Chunlei ZhangRunfeng Zhang
Oct 22, 2013·Journal of Applied Genetics·Amrutlal K PatelV V S Suryanarayana
Apr 26, 2006·Genetica·Estela BastosRobert Renaville
Apr 24, 2008·Biochemical Genetics·Chuanying PanXinzhuang Wang
Nov 14, 2007·Journal of Applied Genetics·Cheng-Yi SongJiu-De Mao
Feb 9, 2012·Molecular Biology Reports·Maria Consuelo MuraVincenzo Carcangiu
Jan 1, 2014·Journal of Animal Science and Technology·Gye-Woong KimHack-Youn Kim
Sep 27, 2014·Molecular Biology Reports·Daniela do Amaral GrossiDanísio Prado Munari
Aug 21, 2003·Journal of Animal Science·G ThallerR Fries
Jun 23, 2012·Molecular Biology Reports·Heng-Yong XuQing Zhu
Oct 20, 1999·Domestic Animal Endocrinology·I ParmentierR Renaville

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