Pitfalls in gastrointestinal permeability measurement in ICU patients with multiple organ failure using differential sugar absorption

Intensive Care Medicine
Heleen M Oudemans-van StraatenDurk F Zandstra

Abstract

To assess whether gastrointestinal permeability (GIP) at intensive care unit (ICU) admission, measured by differential sugar absorption, is related to severity of disease and multiple organ failure (MOF). Post hoc, to analyse the relation between the urinary sugar recovery and renal function. Prospective observational cohort study. Eighteen-bed general ICU of a teaching hospital. Sixty-four ventilated patients admitted with MOF. GIP was assessed within 24 h using cellobiose (C), sucrose (S) and mannitol (M) absorption. Severity of disease: APACHE II and III, SAPS II and MPM II systems. Organ failure: SOFA, MODS and Goris score. The median urinary recovery of C was 0.147% (range 0.004-2.145%), of S 0.249% (0.001-3.656%) and of M 10.7% (0.6-270%). In 16 patients, M recovery was over 100% of the oral dose. They received red blood cell transfusion (RBC). In the non-transfused, the median cellobiose/mannitol (CM) ratio was 0.015 (0.0004-0.550). CM ratio was not related to severity of disease and inversely related to the SOFA score ( r=-0.30, p=0.04). Post hoc regression analysis showed that recoveries of C, S and M were positively related to urinary volume. Recoveries of C and S, but not of M, were positively related to creatinine c...Continue Reading

Citations

Sep 12, 2006·Intensive Care Medicine·Vibeke L JørgensenAnders Perner
Jul 10, 2007·Intensive Care Medicine·Falco HietbrinkLuke P H Leenen
Jun 9, 2006·World Journal of Emergency Surgery : WJES·F HietbrinkLph Leenen
Jul 1, 2005·Critical Care : the Official Journal of the Critical Care Forum·Ilkka ParviainenStephan M Jakob
Feb 18, 2011·Current Opinion in Supportive and Palliative Care·Bohuslav Melichar, Michaela Zezulová
Mar 9, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Bohuslav MelicharDagmar Solichová
Jan 1, 2007·Acta Clinica Belgica·A ReintamJ Starkopf
Feb 27, 2009·Acta Anaesthesiologica Scandinavica·A ReintamJ Starkopf
Aug 28, 2014·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Katri V TyppoFayez K Ghishan
Dec 17, 2010·World Journal of Gastrointestinal Surgery·Joep GrootjansWim A Buurman
Jul 28, 2016·World Journal of Nephrology·Matty L TerpstraFrederike J Bemelman
Apr 6, 2011·Journal of Intensive Care Medicine·J H C PetersA A van Bodegraven
Apr 17, 2004·British Journal of Haematology·Michael Ellis
Mar 23, 2017·Critical Care : the Official Journal of the Critical Care Forum·Christian GreisTobias Liebregts
Oct 16, 2007·Anaesthesia and Intensive Care·F M P van HarenJ G Van der Hoeven
May 18, 2020·Critical Care : the Official Journal of the Critical Care Forum·Annika Reintam BlaserUNKNOWN Working Group on Gastrointestinal Function within the Section of Metabolism, Endocrinology and Nutrition (MEN Section) of ES
Mar 25, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Oana A Tatucu-BabetAudrey C Tierney
Aug 10, 2021·Beneficial Microbes·E Arvidsson NordströmN Larsson

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