Pitfalls in studies of eosinopenia and neutrophil-to-lymphocyte count ratio

Infectious Diseases
Stamatis KarakonstantisCharalampos Lydakis

Abstract

There is a number of publications evaluating the eosinophil count and the neutrophil-to-lymphocyte count ratio for diagnosis, prognosis or monitoring of patients. Of special interest is the use of these parameters for discrimination between the different causes of fever (e.g. bacterial versus viral vs. non-infectious causes of fever) and for monitoring the efficacy of therapy and predict the course of the patient. However, pitfalls in previous study designs prevent applicability to clinical practice. Here, we provide a short review of the relevant literature and summarize important factors that should be taken into account when designing studies, with special attention to the selection of a proper and clinically meaningful study population and the effects of the stress response and of corticosteroids.

References

Jan 1, 1981·The Journal of Clinical Investigation·L C AltmanM F Mullarkey
Jun 1, 1980·The Journal of Clinical Investigation·D A BassC E McCall
Jun 28, 2003·La Revue de médecine interne·H GilJ-L Dupond
Jan 1, 1952·Acta Medica Scandinavica·F DREYFUSS, S FELDMAN
Jul 1, 1956·The American Journal of the Medical Sciences·K KIRKEBY
Jan 17, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mary Jane SetterbergRaymond A Smego
Apr 26, 2008·Critical Care : the Official Journal of the Critical Care Forum·Khalid AbidiRedouane Abouqal
Jun 13, 2009·Critical Care : the Official Journal of the Critical Care Forum·Alex SmithsonJosep-Maria Nicolas
Mar 9, 2010·European Journal of Internal Medicine·Stamatis P EfstathiouTheodore D Mountokalakis
Jul 14, 2010·Trends in Immunology·Charlotte SummersEdwin R Chilvers
Mar 4, 2011·Intensive Care Medicine·Khalid AbidiRedouane Abouqal
Dec 15, 2011·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Richard Warrington, Fanny Silviu-Dan
Oct 11, 2012·PloS One·Cornelis P C de JagerRobert J F Laheij
Jan 3, 2013·Journal of Travel Medicine·Dimitrios FarmakiotisChristina M Coyle
Sep 6, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H FlickM Hoenigl
Jun 7, 2014·Critical Care : the Official Journal of the Critical Care Forum·Jose Garnacho-MonteroAntonio Puppo-Moreno
Aug 1, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dimitrios FarmakiotisElpiniki Vassiliadou
May 20, 2015·The Journal of Allergy and Clinical Immunology·Kimberly G BlumenthalSandra B Nelson
Jun 18, 2015·Journal of Intensive Care·Emmanuel Jesús Escobar-ValdiviaRoberto Mercado-Longoría
Oct 27, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Fei WangXiao Wu
Oct 22, 2016·The Journal of Trauma and Acute Care Surgery·Evren DilektasliDemetrios Demetriades
Apr 2, 2016·La Revue de médecine interne·C E LavoignetP Bilbault
Jun 9, 2016·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Dimple AnandDebashish Dhar
Aug 21, 2016·British Journal of Clinical Pharmacology·Elena RamírezJesús Frías
Nov 4, 2016·The American Journal of Emergency Medicine·Sung Yeon HwangMin Seob Sim
Nov 22, 2016·Primary Care·Anna Kovalszki, Peter F Weller
Nov 24, 2016·The American Journal of Emergency Medicine·Yaming SunChun-Feng Liu
May 19, 2017·The Journal of Head Trauma Rehabilitation·Weiqiang ChenShousen Wang
Jun 20, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·B DavidoJ Salomon
Jul 25, 2017·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Asli BolayirSuat Ahmet Topaktas
Sep 3, 2017·Infection·Are NaessHaakon Sjursen

❮ Previous
Next ❯

Citations

May 3, 2020·Advances in Rheumatology·Tolga Düzenli, Emre Ata
Sep 15, 2020·Melanoma Management·Joshua T CohenMichael P Vezeridis
Mar 27, 2020·Journal of Clinical Medicine·Till van GemmerenKarin Weissenborn
Oct 17, 2020·Curēus·Uzma IshaqUmar Ikram
Nov 18, 2020·Diagnostic Microbiology and Infectious Disease·Lin SongXian-Zhang Huang
Nov 15, 2020·Langenbeck's Archives of Surgery·Dedrick Kok Hong Chan, Jia Jun Ang
Dec 7, 2020·The Journal of Surgical Research·Jia Jun AngDedrick Kok Hong Chan
Feb 28, 2021·Scientific Reports·Tomasz KaraudaAdam Jerzy Białas
Sep 1, 2019·The Journal of Allergy and Clinical Immunology. in Practice·Pavel KolkhirMarcus Maurer
Dec 6, 2018·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Stamatis KarakonstantisCharalampos Lydakis
Mar 14, 2019·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Stamatis KarakonstantisCharalampos Lydakis
Apr 3, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Tolga Düzenli, Hüseyin Köseoğlu
Aug 28, 2021·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jindrich KopeckyAneta Kyllarova

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada
Ali Gürağaç, Zafer Demirer
Indian Journal of Psychology
R B MATHUR, J C SACHDEV
© 2022 Meta ULC. All rights reserved